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Target General Information |
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Target ID |
T10147 |
Target Info
|
Target Name |
Protein-tyrosine phosphatase sigma (R-PTP-sigma) |
Synonyms |
Receptor-type tyrosine-protein phosphatase sigma; Receptor-type tyrosine-protein phosphatase S; R-PTP-S |
Target Type |
Successful Target |
Gene Name |
PTPRS |
Biochemical Class |
Phosphoric monoester hydrolase |
UniProt ID |
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Co-Targets of This Target |
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Co-Target Name |
Escherichia coli Type IV secretion-like conjugative transfer relaxase protein TraI (Ecoli traI) |
Co-Target |
UniProt ID |
B1LRJ1_ECOSM
|
Gene Name |
Ecoli traI |
Representative Drug(s) |
Etidronic acid |
Drug Info
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Ki = 3 nM |
[1] |
References |
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REF 1 |
Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12282-7.
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