COVID-19 Drug Information
Drug General Information | Top | |||
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Drug ID |
D05TMW
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Drug Name |
Methotrexate
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Synonyms |
methotrexate; 59-05-2; Amethopterin; Rheumatrex; Trexall; Metatrexan; Hdmtx; Abitrexate; Methylaminopterinum; Methylaminopterin; MTX; 4-Amino-10-methylfolic acid; Methotrexate hydrate; Metotrexato; Methotrexatum; Maxtrex; Rasuvo; A-Methopterin; A-Methpterin; Amethopterin L-; Folex-Pfs; Methotrexat-Ebewe; N-Bismethylpteroylglutamic acid; Methotrexate, L-; Methoxtrexate; NSC-740; NCI-C04671; Antifolan; Metotressato [DCIT]; Mexate-Aq; CL-14377; UNII-YL5FZ2; Methotrexate
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Drug Type |
Small molecular drug
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Indication | Coronavirus Disease 2019 (COVID-19) | Phase 1/2 | [1] | |
Other Indication | Choriocarcinoma | Approved | [2] | |
Therapeutic Class |
Antiviral Agents
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Structure |
Download2D MOL |
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Formula |
C20H22N8O5
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Canonical SMILES |
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
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InChI |
1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
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InChIKey |
FBOZXECLQNJBKD-ZDUSSCGKSA-N
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CAS Number |
CAS 59-05-2
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:44185
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References | Top | |||
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1 | ClinicalTrials.gov (NCT04352465) Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients. U.S. National Institutes of Health. | |||
2 | FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 040632. |
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