Drug General Information
Drug ID
D07AEO
Drug Name
Isotretinoin
Synonyms
Accutane; 13-cis-Retinoic acid; Roaccutane; Neovitamin A acid; 13-cis-Vitamin A acid; 13-cis retinoic acid; Claravis; Amnesteem; Isotrex; Teriosal; Sotret; isotretinoino; Isotretinoinum; Isotretinoine; Roaccutan; 13-RA; Roacutan; Absorica; ISOTRETINON; Isotretinoine [INN-French]; Isotretinoinum [INN-Latin]; Isotretinoino [INN-Spanish]; CIP-Isotretinoin; Accutane (TN); Isotretinoin (USP); Ro-4-3780; UNII-EH28UP18IF; CCRIS 4286; HSDB 3929
Drug Type
Small molecular drug
Indication Coronavirus Disease 2019 (COVID-19) Phase 3 [1]
Therapeutic Class
Antiviral Agents
Structure
Download
2D MOL

3D MOL

Formula
C20H28O2
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChIKey
SHGAZHPCJJPHSC-XFYACQKRSA-N
CAS Number
CAS 4759-48-2
PubChem Compound ID
Target
Target(s) COVID-19 papain-like proteinase (PL-PRO) Target Info Inhibitor [1]
Isotretinoin is a Potential papain like protease (PLpro) inhibitor which is a protein encoded by SARS-CoV-2 genes and considered one of the proteins that should be targeted in COVID-19 treatment.
References
1 ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health.

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