Drug General Information
Drug ID
D0V6GN
Drug Name
Chlorpromazine
Synonyms
Aminasine; Aminazin; Aminazine; Ampliactil; Amplicitil; Amplictil; BC 135; Chlor-PZ; Chlor-Promanyl; Chlordelazine; Chlorderazin; Chloropromazine; Chlorpromados; Chlorpromanyl (discontinued); Chlorpromazin; Chlorpromazine (USP/INN); Chlorpromazine Tannate; Chlorpromazine [USAN:INN:BAN]; Chlorpromazinum; Chlorpromazinum [INN-Latin]; Clorpromazina; Clorpromazina [INN-Spanish]; Clorpromazina [Italian]; Contomin; Cromedazine; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746; JHICC02042; Largactil; Largactil (TN); Largactil Liquid; Largactil Oral Drops; Largactilothiazine; Largactyl; Megaphen; Novo-Chlorpromazine; Novomazina; Phenactyl; Phenathyl; Phenothiazine hydrochloride; Plegomasine; Plegomazin; Prazilpromactil; Proma; Promactil; Promazil; Propaphen; Propaphenin; Prozil; Psychozine; SKF 2601-A; SKF 2601A; SKF-2601; Sanopron; Thorazine; Thorazine (TN); Thorazine Spansule; Thorazine Suppositories; Thorazine hydrochloride; Torazina; Wintermin; Z80
Drug Type
Small molecular drug
Indication Coronavirus Disease 2019 (COVID-19) Phase 3 [1]
Middle East Respiratory Syndrome (MERS) Investigative [2]
Severe acute respiratory syndrome (SARS) Investigative [2]
Other Indication Schizophrenia Withdrawn from market [3]
Therapeutic Class
Antiviral Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C17H19ClN2S
InChI
1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
InChIKey
ZPEIMTDSQAKGNT-UHFFFAOYSA-N
CAS Number
CAS 50-53-3
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:3647
Target
Target(s) HUMAN clathrin-mediated endocytosis (RME) Target Info Inhibitor [2], [4]
Chlorpromazine,an inhibitor for clathrin-dependent endocytosis, possess significant inhibitory effect on the entry of SARS CoV-2. Chlorpromazine is active against numerous CoVs, including SARS-CoV and MERS-CoV by affecting the assembly of clathrin-coated pits at the plasma membrane and targeting the endocytosis of CoV during cell entry.
References
1 ClinicalTrials.gov (NCT04366739) Repurposing of Chlorpromazine in Covid-19 Treatment. U.S. National Institutes of Health.
2 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19. Int J Biol Sci. 2020 Mar 15;16(10):1724-1731.

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