Target Information
Target General Infomation | Top | ||||
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Target ID |
T10783
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Target Name |
MERS-CoV spike glycoprotein S2' HR1 region (S S2'HR1)
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Synonyms |
MERS-CoV S glycoprotein S2' heptad repeat 1 region; MERS-CoV Spike glycoprotein S2' heptad repeat 1 region; MERS-CoV E2 S2' heptad repeat 1 region; MERS-CoV Peplomer protein S2' heptad repeat 1 region
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Gene Name |
MERS-CoV S
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Target Status |
Literature-reported Target
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[1] | |||
Disease | [+] 1 Target-related Diseases | + | |||
1 | Middle East Respiratory Syndrome [ICD-11: 1D64] | ||||
Function |
Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
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BioChemical Class |
Betacoronaviruses spike protein family.
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UniProt ID | |||||
Sequence |
SAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAY
TSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGA MQTGFTTTNEAFRKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQI DRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFV VNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYT GSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIP NFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKELGNYTYYNKWPWYIWLGFIAGL VALALCVFFILCCTGCGTNCMGKLKCNRCCDRYEEYDLEPHKVHVH |
Drugs and Modes of Action | Top | ||||
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Investigative agents | [+] 1 Investigative agents | + | |||
1 | Fusion peptide EK1 | Drug Info | Investigative | MERS | [1] |
Mode of Action | [+] 1 Modes of Action | + | |||
Inhibitor | [+] 1 Inhibitor drugs | + | |||
1 | Fusion peptide EK1 | Drug Info | [1] |
References | Top | ||||
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1 | A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv. 2019 Apr 10;5(4):eaav4580. |
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