Target Information
Target General Infomation | Top | ||||
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Target ID |
T86805
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Target Name |
HUMAN eukaryotic initiation factor-4A (eIF4A)
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Synonyms |
eIF-4A; ATP-dependent RNA helicase Eif4a
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Gene Name |
EIF4A1; EIF4A2; EIF4A3
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Target Status |
Literature-reported Target
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[1] | |||
Disease | [+] 1 Target-related Diseases | + | |||
1 | Middle East Respiratory Syndrome [ICD-11: 1D64] | ||||
Function |
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon
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BioChemical Class |
eIF4A subfamily
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UniProt ID | |||||
Sequence |
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI |
Drugs and Modes of Action | Top | ||||
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Investigative agents | [+] 1 Investigative agents | + | |||
1 | Silvestrol | Drug Info | Investigative | MERS | [1] |
Mode of Action | [+] 1 Modes of Action | + | |||
Inhibitor | [+] 1 Inhibitor drugs | + | |||
1 | Silvestrol | Drug Info | [1] |
References | Top | ||||
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1 | Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129. |
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