Target General Infomation
Target ID
T88015
Target Name
COVID-19 3C-like protease (3CLpro)
Synonyms
COVID-19 3CL-PRO; COVID-19 3CLp; COVID-19 nsp5
Gene Name
COVID-19 rep
Target Status
Target in Phase 3 Trial
[1]
Disease [+] 1 Target-related Diseases +
1 COVID-19 [ICD-11: 1D6Y]
Function
Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1''-phosphate (ADRP).
BioChemical Class
Coronaviruses polyprotein 1ab family
UniProt ID
R1AB_SARS2(3264-3569)
EC Number
EC 3.4.22.69
Sequence
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIR
KSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGN
FYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQC
SGVTFQ
Drugs and Modes of Action
Drugs in Phase 3 Trial [+] 5 Drugs in Phase 3 Trial +
1 Lopinavir + ritonavir Drug Info Phase 3 Trial COVID-19 [2]
2 ASC09 + ritonavir + oseltamivir Drug Info Phase 3 Trial COVID-19 [3]
3 Lopinavir + ritonavir + favipiravir Drug Info Phase 3 Trial COVID-19 [4]
4 Darunavir + cobicistat Drug Info Phase 3 Trial COVID-19 [5]
5 Lopinavir + ritonavir + oseltamivir Drug Info Phase 3 Trial COVID-19 [4]
Drugs in Phase 2 Trial [+] 1 Drugs in Phase 2 Trial +
1 Lopinavir + ritonavir + ribavirin + interferon beta-1b Drug Info Phase 2 Trial COVID-19 [6]
Drugs in Phase 1 Trial [+] 2 Drugs in Phase 1 Trial +
1 Lopinavir + ritonavir + interferon apha + traditional chinese medicines granules Drug Info Phase 1 Trial COVID-19 [7]
2 ASC09 + ritonavir Drug Info Phase 1 Trial COVID-19 [8]
Preclinical Drugs [+] 1 Preclinical Drugs +
1 Lopinavir + ritonavir + interferon alpha Drug Info Preclinical COVID-19 [9]
Investigative agents [+] 2 Investigative agents +
1 GC376 Drug Info Investigative COVID-19 [10]
2 Boceprevir Drug Info Investigative COVID-19 [10]
Mode of Action [+] 1 Modes of Action +
Inhibitor [+] 11 Inhibitor drugs +
1 ASC09 + ritonavir Drug Info [1]
2 ASC09 + ritonavir + oseltamivir Drug Info [1]
3 Darunavir + cobicistat Drug Info [1]
4 Lopinavir + ritonavir Drug Info [1]
5 Lopinavir + ritonavir + favipiravir Drug Info [1]
6 Lopinavir + ritonavir + oseltamivir Drug Info [1]
7 Lopinavir + ritonavir + ribavirin + interferon beta-1b Drug Info [1]
8 Lopinavir + ritonavir + interferon apha + traditional chinese medicines granules Drug Info [1]
9 GC376 Drug Info [10]
10 Lopinavir + ritonavir + interferon alpha Drug Info [1]
11 Boceprevir Drug Info [10]
References
1 Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381.
2 ClinicalTrials.gov (NCT04315948) Trial of Treatments for COVID-19 in Hospitalized Adults
3 ClinicalTrials.gov (NCT04261270) A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia
4 ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial
5 ClinicalTrials.gov (NCT04252274) Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19
6 ClinicalTrials.gov (NCT04276688) Lopinavir/ Ritonavir, Ribavirin and IFN-beta Combination for nCoV Treatment
7 ClinicalTrials.gov (NCT04251871) Treatment and Prevention of Traditional Chinese Medicines (TCMs) on 2019-nCoV Infection
8 ClinicalTrials.gov (NCT04261907) Evaluating and Comparing the Safety and Efficiency of ASC09/Ritonavir and Lopinavir/Ritonavir for Novel Coronavirus Infection
9 ClinicalTrials.gov (NCT04275388) Xiyanping Injection for the Treatment of New Coronavirus Infected Pneumonia
10 Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 2020. April 20. doi: https://doi.org/10.1101/2020.04.20.051581

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