Target General Infomation
Target ID
T99009
Target Name
HUMAN dihydroorotate dehydrogenase (DHODH)
Synonyms
Dihydroorotate oxidase; Dihydroorotate dehydrogenase (quinone), mitochondrial; DHOdehase; DHODH
Gene Name
DHODH
Target Status
Target in Phase 2 Trial
[1]
Disease [+] 3 Target-related Diseases +
1 COVID-19 [ICD-11: 1D6Y]
2 Middle East Respiratory Syndrome [ICD-11: 1D64]
3 Severe acute respiratory syndrome [ICD-11: 1D65]
Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
BioChemical Class
CH-CH donor oxidoreductase
UniProt ID
PYRD_HUMAN
EC Number
EC 1.3.5.2
Sequence
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Drugs and Modes of Action
Drugs in Phase 2 Trial [+] 1 Drugs in Phase 2 Trial +
1 IMU-838 Drug Info Phase 2 Trial COVID-19 [2]
Drugs in Phase 1 Trial [+] 1 Drugs in Phase 1 Trial +
1 Leflunomide Drug Info Phase 1 Trial COVID-19 [3]
Preclinical Drugs [+] 1 Preclinical Drugs +
1 FA-613 Drug Info Preclinical MERS [1]
Mode of Action [+] 1 Modes of Action +
Inhibitor [+] 3 Inhibitor drugs +
1 IMU-838 Drug Info [4]
2 Leflunomide Drug Info [4], [5]
3 FA-613 Drug Info [1]
Tissue/Disease-Specific Protein Abundances of This Target
      Tissue-specific Protein Abundances in Healthy Individuals Click to Show/Hide
      ICD Disease Classification 01 Certain infectious or parasitic disease Click to Show/Hide
                  ICD-11: 1C1H     Necrotising ulcerative gingivitis Click to Show/Hide
The Studied Tissue     Gingival tissue
The Specified Disease     Bacterial infection of gingival [ICD-11:1C1H]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.03820783; Fold-change: -0.050702941; Z-score: -0.166468667
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 1E30     Influenza Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Influenza [ICD-11:1.00E+30]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.25154123; Fold-change: 0.191298612; Z-score: 1.277526246
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 1E51     Chronic viral hepatitis Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Chronic hepatitis C [ICD-11:1E51.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.176620902; Fold-change: -0.220881459; Z-score: -0.656778147
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 1G41     Sepsis with septic shock Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Sepsis with septic shock [ICD-11:1G41]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 2.32E-08; Fold-change: -0.119899985; Z-score: -0.398555884
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA40     Respiratory syncytial virus infection Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Pediatric respiratory syncytial virus infection [ICD-11:CA40.11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.453022445; Fold-change: -0.078804979; Z-score: -0.265484631
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA42     Rhinovirus infection Click to Show/Hide
The Studied Tissue     Nasal epithelium tissue
The Specified Disease     Rhinovirus infection [ICD-11:CA42.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.213052077; Fold-change: -0.036078906; Z-score: -0.268866687
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: KA60     Neonatal sepsis Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Neonatal sepsis [ICD-11:KA60]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000483455; Fold-change: -0.145862325; Z-score: -0.556629008
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 02 Neoplasm Click to Show/Hide
                  ICD-11: 2A00     Brain cancer Click to Show/Hide
The Studied Tissue     Nervous tissue
The Specified Disease     Glioblastopma [ICD-11:2A00.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.75E-69; Fold-change: 0.407108228; Z-score: 1.243773508
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Brain stem tissue
The Specified Disease     Glioma [ICD-11:2A00.0Y-2A00.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.55824135; Fold-change: -0.015922464; Z-score: -0.265916863
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     White matter tissue
The Specified Disease     Glioma [ICD-11:2A00.0Y-2A00.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.114177343; Fold-change: 0.110832375; Z-score: 0.396446229
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Brain stem tissue
The Specified Disease     Neuroectodermal tumour [ICD-11:2A00.11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 9.74E-06; Fold-change: 0.539483226; Z-score: 2.368017746
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2A20     Myeloproliferative neoplasm Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Myelofibrosis [ICD-11:2A20.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.044328636; Fold-change: 0.22059279; Z-score: 1.480654638
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Whole blood
The Specified Disease     Polycythemia vera [ICD-11:2A20.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.00059746; Fold-change: 0.17417058; Z-score: 1.095484645
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2A36     Myelodysplastic syndrome Click to Show/Hide
The Studied Tissue     Bone marrow
The Specified Disease     Myelodysplastic syndrome [ICD-11:2A36-2A3Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000440996; Fold-change: 0.501956452; Z-score: 1.171650211
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.437687746; Fold-change: 0.243796236; Z-score: 0.408836977
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2A81     Diffuse large B-cell lymphoma Click to Show/Hide
The Studied Tissue     Tonsil tissue
The Specified Disease     Diffuse large B-cell lymphoma [ICD-11:2A81]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.844560608; Fold-change: -0.060700804; Z-score: -0.300868064
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2A83     Plasma cell neoplasm Click to Show/Hide
The Studied Tissue     Bone marrow
The Specified Disease     Multiple myeloma [ICD-11:2A83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.414506778; Fold-change: -0.068927972; Z-score: -0.205459004
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Peripheral blood
The Specified Disease     Multiple myeloma [ICD-11:2A83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.547656413; Fold-change: -0.139040976; Z-score: -0.82761365
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B33     Leukaemia Click to Show/Hide
The Studied Tissue     Bone marrow
The Specified Disease     Acute myelocytic leukaemia [ICD-11:2B33.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.21E-11; Fold-change: 0.212159165; Z-score: 0.641732871
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B6E     Oral cancer Click to Show/Hide
The Studied Tissue     Oral tissue
The Specified Disease     Oral cancer [ICD-11:2B6E]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.556798187; Fold-change: -0.127006814; Z-score: -0.365408369
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.710764432; Fold-change: 0.085807983; Z-score: 0.277331607
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B70     Esophageal cancer Click to Show/Hide
The Studied Tissue     Esophagus
The Specified Disease     Esophagal cancer [ICD-11:2B70]
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.025432624; Fold-change: 0.655137775; Z-score: 1.689750513
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B72     Stomach cancer Click to Show/Hide
The Studied Tissue     Gastric tissue
The Specified Disease     Gastric cancer [ICD-11:2B72]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.922392848; Fold-change: -0.113506841; Z-score: -0.214428344
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.018127809; Fold-change: -0.196106155; Z-score: -0.984299619
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B90     Colon cancer Click to Show/Hide
The Studied Tissue     Colon tissue
The Specified Disease     Colon cancer [ICD-11:2B90]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 7.29E-19; Fold-change: 0.328080425; Z-score: 0.946239134
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.000115928; Fold-change: 0.152439034; Z-score: 0.405418656
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2B92     Rectal cancer Click to Show/Hide
The Studied Tissue     Rectal colon tissue
The Specified Disease     Rectal cancer [ICD-11:2B92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.86095192; Fold-change: -0.040143481; Z-score: -0.086596488
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.025692248; Fold-change: 0.232286564; Z-score: 1.193865965
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C10     Pancreatic cancer Click to Show/Hide
The Studied Tissue     Pancreas
The Specified Disease     Pancreatic cancer [ICD-11:2C10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.029277676; Fold-change: -0.472823965; Z-score: -1.478065557
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.002067881; Fold-change: 0.073300427; Z-score: 0.269767775
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C12     Liver cancer Click to Show/Hide
The Studied Tissue     Liver tissue
The Specified Disease     Liver cancer [ICD-11:2C12.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.35E-15; Fold-change: -1.902998614; Z-score: -2.018708302
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 1.13E-40; Fold-change: -1.708598098; Z-score: -1.550881953
The Expression Level of Disease Section Compare with the Other Disease Section     p-value: 0.039881908; Fold-change: -1.857817609; Z-score: -1.706351187
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Target expression in tissue other than the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C25     Lung cancer Click to Show/Hide
The Studied Tissue     Lung tissue
The Specified Disease     Lung cancer [ICD-11:2C25]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 3.46E-08; Fold-change: 0.131465393; Z-score: 0.454222298
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.003488398; Fold-change: 0.092169063; Z-score: 0.296295348
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C30     Skin cancer Click to Show/Hide
The Studied Tissue     Skin
The Specified Disease     Melanoma [ICD-11:2C30]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.120726899; Fold-change: 0.057589597; Z-score: 0.136284343
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Skin
The Specified Disease     Skin cancer [ICD-11:2C30-2C3Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.38E-08; Fold-change: 0.146380579; Z-score: 0.358593061
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.107127939; Fold-change: -0.245486696; Z-score: -0.536327275
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C6Z     Breast cancer Click to Show/Hide
The Studied Tissue     Breast tissue
The Specified Disease     Breast cancer [ICD-11:2C60-2C6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.891706345; Fold-change: -0.048365276; Z-score: -0.099055335
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.03463755; Fold-change: 0.042802519; Z-score: 0.129365879
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C73     Ovarian cancer Click to Show/Hide
The Studied Tissue     Ovarian tissue
The Specified Disease     Ovarian cancer [ICD-11:2C73]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.4263722; Fold-change: -0.075614938; Z-score: -0.321117399
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.014720321; Fold-change: -0.32252425; Z-score: -0.799272722
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C77     Cervical cancer Click to Show/Hide
The Studied Tissue     Cervical tissue
The Specified Disease     Cervical cancer [ICD-11:2C77]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.341213621; Fold-change: 0.138961307; Z-score: 0.500743157
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C78     Uterine cancer Click to Show/Hide
The Studied Tissue     Endometrium tissue
The Specified Disease     Uterine cancer [ICD-11:2C78]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.008147255; Fold-change: -0.067320794; Z-score: -0.118871639
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.620803922; Fold-change: -0.2722074; Z-score: -0.812363282
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C82     Prostate cancer Click to Show/Hide
The Studied Tissue     Prostate
The Specified Disease     Prostate cancer [ICD-11:2C82]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 3.64E-08; Fold-change: 0.833584251; Z-score: 1.915013792
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C90     Renal cancer Click to Show/Hide
The Studied Tissue     Kidney
The Specified Disease     Renal cancer [ICD-11:2C90-2C91]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.058202608; Fold-change: 0.109643235; Z-score: 0.331164061
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.005544138; Fold-change: 0.311325377; Z-score: 0.805107999
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C92     Ureter cancer Click to Show/Hide
The Studied Tissue     Urothelium
The Specified Disease     Ureter cancer [ICD-11:2C92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.353031391; Fold-change: 0.111919294; Z-score: 0.452305597
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2C94     Bladder cancer Click to Show/Hide
The Studied Tissue     Bladder tissue
The Specified Disease     Bladder cancer [ICD-11:2C94]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.027632746; Fold-change: 0.225948278; Z-score: 1.297344703
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2D02     Retinal cancer Click to Show/Hide
The Studied Tissue     Uvea
The Specified Disease     Retinoblastoma [ICD-11:2D02.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.001171298; Fold-change: 0.618771639; Z-score: 4.775429919
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2D10     Thyroid cancer Click to Show/Hide
The Studied Tissue     Thyroid
The Specified Disease     Thyroid cancer [ICD-11:2D10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.53E-12; Fold-change: -0.252324231; Z-score: -0.950762262
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.000554367; Fold-change: -0.12216356; Z-score: -0.510148688
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2D11     Adrenal cancer Click to Show/Hide
The Studied Tissue     Adrenal cortex
The Specified Disease     Adrenocortical carcinoma [ICD-11:2D11.Z]
The Expression Level of Disease Section Compare with the Other Disease Section     p-value: 0.003190054; Fold-change: -0.062959411; Z-score: -0.52040692
Target expression in the diseased tissue of patients
Target expression in tissue other than the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2D12     Endocrine gland neoplasm Click to Show/Hide
The Studied Tissue     Pituitary tissue
The Specified Disease     Pituitary cancer [ICD-11:2D12]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.001318404; Fold-change: 0.226923385; Z-score: 1.389607339
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Pituitary tissue
The Specified Disease     Pituitary gonadotrope tumour [ICD-11:2D12]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.008223782; Fold-change: 0.224470566; Z-score: 1.155275739
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 2D42     Head and neck cancer Click to Show/Hide
The Studied Tissue     Head and neck tissue
The Specified Disease     Head and neck cancer [ICD-11:2D42]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 1.53E-10; Fold-change: -0.185575825; Z-score: -0.574222963
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 03 Disease of the blood or blood-forming organs Click to Show/Hide
                  ICD-11: 3A51     Sickle cell disorder Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Sickle cell disease [ICD-11:3A51.0-3A51.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.522603436; Fold-change: -0.102675595; Z-score: -0.671940868
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 3A70     Aplastic anaemia Click to Show/Hide
The Studied Tissue     Bone marrow
The Specified Disease     Shwachman-Diamond syndrome [ICD-11:3A70.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.010102284; Fold-change: -0.294844608; Z-score: -1.269164781
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 3B63     Thrombocytosis Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Thrombocythemia [ICD-11:3B63]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.008774708; Fold-change: 0.171848006; Z-score: 1.169267253
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 3B64     Thrombocytopenia Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Thrombocytopenia [ICD-11:3B64]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.575185146; Fold-change: 0.094052955; Z-score: 0.245657897
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 04 Disease of the immune system Click to Show/Hide
                  ICD-11: 4A00     Immunodeficiency Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Immunodeficiency [ICD-11:4A00-4A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.08062507; Fold-change: -0.024838634; Z-score: -0.263696244
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 4A40     Lupus erythematosus Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Lupus erythematosus [ICD-11:4A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.864891061; Fold-change: 0.079107539; Z-score: 0.100858361
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 4A42     Systemic sclerosis Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Scleroderma [ICD-11:4A42.Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000390021; Fold-change: 0.303843697; Z-score: 1.693813857
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 4A43     Systemic autoimmune disease Click to Show/Hide
The Studied Tissue     Salivary gland tissue
The Specified Disease     Sjogren's syndrome [ICD-11:4A43.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.892814568; Fold-change: -0.156298049; Z-score: -0.536802367
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.474250409; Fold-change: 0.025413322; Z-score: 0.507879908
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 4A62     Behcet disease Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Behcet's disease [ICD-11:4A62]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.448970656; Fold-change: 0.021501695; Z-score: 0.131159711
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 4B04     Monocyte count disorder Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Autosomal dominant monocytopenia [ICD-11:4B04]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.394403758; Fold-change: -0.018111642; Z-score: -0.086175347
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 05 Endocrine, nutritional or metabolic disease Click to Show/Hide
                  ICD-11: 5A11     Type 2 diabetes mellitus Click to Show/Hide
The Studied Tissue     Omental adipose tissue
The Specified Disease     Obesity related type 2 diabetes [ICD-11:5A11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.033165658; Fold-change: -0.185159196; Z-score: -1.072519697
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Liver tissue
The Specified Disease     Type 2 diabetes [ICD-11:5A11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.876157837; Fold-change: -0.027740395; Z-score: -0.09170086
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 5A80     Ovarian dysfunction Click to Show/Hide
The Studied Tissue     Vastus lateralis muscle
The Specified Disease     Polycystic ovary syndrome [ICD-11:5A80.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.335287323; Fold-change: -0.063553405; Z-score: -0.664049656
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 5B81     Obesity Click to Show/Hide
The Studied Tissue     Subcutaneous adipose tissue
The Specified Disease     Obesity [ICD-11:5B81]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.162852758; Fold-change: 0.029922582; Z-score: 0.136419304
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 5C51     Inborn carbohydrate metabolism disorder Click to Show/Hide
The Studied Tissue     Biceps muscle
The Specified Disease     Pompe disease [ICD-11:5C51.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.009766203; Fold-change: -0.15080092; Z-score: -0.864462145
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 5C56     Lysosomal disease Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Batten disease [ICD-11:5C56.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.049744511; Fold-change: -0.179160111; Z-score: -1.157988299
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 5C80     Hyperlipoproteinaemia Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Familial hypercholesterolemia [ICD-11:5C80.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.691291892; Fold-change: -0.013980946; Z-score: -0.099732156
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Whole blood
The Specified Disease     Familial hypercholesterolemia [ICD-11:5C80.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.017315447; Fold-change: -0.103096665; Z-score: -0.403695878
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 06 Mental, behavioural or neurodevelopmental disorder Click to Show/Hide
                  ICD-11: 6A02     Autism spectrum disorder Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Autism [ICD-11:6A02]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.774926092; Fold-change: 0.045087332; Z-score: 0.13879844
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 6A20     Schizophrenia Click to Show/Hide
The Studied Tissue     Superior temporal cortex
The Specified Disease     Schizophrenia [ICD-11:6A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.696334073; Fold-change: 0.055688362; Z-score: 0.449689702
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Prefrontal cortex
The Specified Disease     Schizophrenia [ICD-11:6A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.621373465; Fold-change: 0.035568249; Z-score: 0.076935021
                  ICD-11: 6A60     Bipolar disorder Click to Show/Hide
The Studied Tissue     Prefrontal cortex
The Specified Disease     Bipolar disorder [ICD-11:6A60-6A6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.856807321; Fold-change: -0.029037594; Z-score: -0.136615715
                  ICD-11: 6A70     Depressive disorder Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Major depressive disorder [ICD-11:6A70-6A7Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.210639209; Fold-change: -0.052243904; Z-score: -0.17732276
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Prefrontal cortex
The Specified Disease     Major depressive disorder [ICD-11:6A70-6A7Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.268846855; Fold-change: -0.061226486; Z-score: -0.287703697
      ICD Disease Classification 08 Disease of the nervous system Click to Show/Hide
                  ICD-11: 8A00     Parkinsonism Click to Show/Hide
The Studied Tissue     Substantia nigra tissue
The Specified Disease     Parkinson's disease [ICD-11:8A00.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.757776292; Fold-change: -0.055806194; Z-score: -0.243912046
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8A01     Choreiform disorder Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Huntington's disease [ICD-11:8A01.10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.682422056; Fold-change: 0.011685525; Z-score: 0.082327865
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8A20     Alzheimer disease Click to Show/Hide
The Studied Tissue     Entorhinal cortex
The Specified Disease     Alzheimer's disease [ICD-11:8A20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.148371448; Fold-change: 0.020338227; Z-score: 0.102599169
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8A2Y     Neurocognitive impairment Click to Show/Hide
The Studied Tissue     White matter tissue
The Specified Disease     HIV-associated neurocognitive impairment [ICD-11:8A2Y-8A2Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.177941651; Fold-change: -0.115859717; Z-score: -0.615737259
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8A40     Multiple sclerosis Click to Show/Hide
The Studied Tissue     Plasmacytoid dendritic cells
The Specified Disease     Multiple sclerosis [ICD-11:8A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.745782692; Fold-change: 0.003889691; Z-score: 0.012724075
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Spinal cord
The Specified Disease     Multiple sclerosis [ICD-11:8A40]
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.32467196; Fold-change: 0.177215074; Z-score: 0.625093902
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8A60     Epilepsy Click to Show/Hide
The Studied Tissue     Peritumoral cortex tissue
The Specified Disease     Epilepsy [ICD-11:8A60-8A6Z]
The Expression Level of Disease Section Compare with the Other Disease Section     p-value: 0.878106499; Fold-change: -0.043957535; Z-score: -0.240618208
Target expression in the diseased tissue of patients
Target expression in tissue other than the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Whole blood
The Specified Disease     Seizure [ICD-11:8A60-8A6Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.670152844; Fold-change: -0.065633272; Z-score: -0.233086478
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8B01     Subarachnoid haemorrhage Click to Show/Hide
The Studied Tissue     Intracranial artery
The Specified Disease     Intracranial aneurysm [ICD-11:8B01.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.107173783; Fold-change: -0.216596822; Z-score: -1.001968934
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8B11     Cerebral ischaemic stroke Click to Show/Hide
The Studied Tissue     Whole blood
The Specified Disease     Cardioembolic stroke [ICD-11:8B11.20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000123444; Fold-change: -0.324701671; Z-score: -1.576246047
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Peripheral blood
The Specified Disease     Ischemic stroke [ICD-11:8B11]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.607739043; Fold-change: 0.106419718; Z-score: 0.491742855
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8B60     Motor neuron disease Click to Show/Hide
The Studied Tissue     Cervical spinal cord
The Specified Disease     Lateral sclerosis [ICD-11:8B60.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.135205552; Fold-change: 0.187037186; Z-score: 0.620164837
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Skin
The Specified Disease     Lateral sclerosis [ICD-11:8B60.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.937592072; Fold-change: -0.026301059; Z-score: -0.346272008
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8C70     Muscular dystrophy Click to Show/Hide
The Studied Tissue     Muscle tissue
The Specified Disease     Myopathy [ICD-11:8C70.6]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.051848385; Fold-change: -0.119767091; Z-score: -0.418606647
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: 8C75     Distal myopathy Click to Show/Hide
The Studied Tissue     Muscle tissue
The Specified Disease     Tibial muscular dystrophy [ICD-11:8C75]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000972425; Fold-change: -0.177786735; Z-score: -0.723565851
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 09 Disease of the visual system Click to Show/Hide
                  ICD-11: 9A96     Anterior uveitis Click to Show/Hide
The Studied Tissue     Peripheral monocyte
The Specified Disease     Autoimmune uveitis [ICD-11:9A96]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.914603943; Fold-change: 0.017737142; Z-score: 0.068592028
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 11 Disease of the circulatory system Click to Show/Hide
                  ICD-11: BA00     Essential hypertension Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Essential hypertension [ICD-11:BA00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.390838493; Fold-change: 0.076408932; Z-score: 1.814500441
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: BA41     Myocardial infarction Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Myocardial infarction [ICD-11:BA41-BA50]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.186422538; Fold-change: -0.213020338; Z-score: -0.395220506
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: BA80     Coronary artery disease Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Coronary artery disease [ICD-11:BA80-BA8Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.480681883; Fold-change: -0.152262299; Z-score: -0.208750916
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: BB70     Aortic valve stenosis Click to Show/Hide
The Studied Tissue     Calcified aortic valve
The Specified Disease     Aortic stenosis [ICD-11:BB70]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.609737342; Fold-change: 0.334062848; Z-score: 0.752256543
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 12 Disease of the respiratory system Click to Show/Hide
                  ICD-11: 7A40     Central sleep apnoea Click to Show/Hide
The Studied Tissue     Hyperplastic tonsil
The Specified Disease     Apnea [ICD-11:7A40]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.927107044; Fold-change: 0.041505873; Z-score: 0.193694568
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA08     Vasomotor or allergic rhinitis Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Olive pollen allergy [ICD-11:CA08.00]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.148863995; Fold-change: 0.482865221; Z-score: 1.404115965
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA0A     Chronic rhinosinusitis Click to Show/Hide
The Studied Tissue     Sinus mucosa tissue
The Specified Disease     Chronic rhinosinusitis [ICD-11:CA0A]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.18703572; Fold-change: -0.02140447; Z-score: -0.093998754
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA22     Chronic obstructive pulmonary disease Click to Show/Hide
The Studied Tissue     Lung tissue
The Specified Disease     Chronic obstructive pulmonary disease [ICD-11:CA22]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.413788055; Fold-change: -0.079919529; Z-score: -0.27619163
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Small airway epithelium
The Specified Disease     Chronic obstructive pulmonary disease [ICD-11:CA22]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.202252822; Fold-change: 0.064637356; Z-score: 0.267467719
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CA23     Asthma Click to Show/Hide
The Studied Tissue     Nasal and bronchial airway
The Specified Disease     Asthma [ICD-11:CA23]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.076428937; Fold-change: -0.073766046; Z-score: -0.193246936
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: CB03     Idiopathic interstitial pneumonitis Click to Show/Hide
The Studied Tissue     Lung tissue
The Specified Disease     Idiopathic pulmonary fibrosis [ICD-11:CB03.4]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.147374747; Fold-change: -0.293409352; Z-score: -1.20792586
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 13 Disease of the digestive system Click to Show/Hide
                  ICD-11: DA0C     Periodontal disease Click to Show/Hide
The Studied Tissue     Gingival tissue
The Specified Disease     Periodontal disease [ICD-11:DA0C]
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.023100354; Fold-change: -0.109715107; Z-score: -0.360195912
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: DA42     Gastritis Click to Show/Hide
The Studied Tissue     Gastric antrum tissue
The Specified Disease     Eosinophilic gastritis [ICD-11:DA42.2]
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.859616768; Fold-change: -0.103491646; Z-score: -0.826358962
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: DB92     Non-alcoholic fatty liver disease Click to Show/Hide
The Studied Tissue     Liver tissue
The Specified Disease     Non alcoholic fatty liver disease [ICD-11:DB92]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.066396893; Fold-change: 1.784319726; Z-score: 1.99215966
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: DB99     Hepatic failure Click to Show/Hide
The Studied Tissue     Liver tissue
The Specified Disease     Liver failure [ICD-11:DB99.7-DB99.8]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 3.03E-08; Fold-change: -3.454442876; Z-score: -6.119892752
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: DD71     Ulcerative colitis Click to Show/Hide
The Studied Tissue     Colon mucosal tissue
The Specified Disease     Ulcerative colitis [ICD-11:DD71]
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.551466023; Fold-change: 0.108512054; Z-score: 0.367365182
Target expression in the diseased tissue of patients
Target expression in tissue other than the diseased tissue of patients
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: DD91     Irritable bowel syndrome Click to Show/Hide
The Studied Tissue     Rectal colon tissue
The Specified Disease     Irritable bowel syndrome [ICD-11:DD91.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.009281987; Fold-change: 0.111959006; Z-score: 0.374711196
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 14 Disease of the skin Click to Show/Hide
                  ICD-11: EA80     Atopic eczema Click to Show/Hide
The Studied Tissue     Skin
The Specified Disease     Atopic dermatitis [ICD-11:EA80]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.093119998; Fold-change: 0.244274415; Z-score: 0.876336895
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: EA90     Psoriasis Click to Show/Hide
The Studied Tissue     Skin
The Specified Disease     Psoriasis [ICD-11:EA90]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000681652; Fold-change: 0.1203172; Z-score: 0.346058729
The Expression Level of Disease Section Compare with the Adjacent Tissue     p-value: 0.133260604; Fold-change: -0.136986936; Z-score: -0.339593304
Target expression in the diseased tissue of patients
Target expression in the normal tissue adjacent to the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: ED63     Acquired hypomelanotic disorder Click to Show/Hide
The Studied Tissue     Skin
The Specified Disease     Vitiligo [ICD-11:ED63.0]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.022744682; Fold-change: 0.186166002; Z-score: 1.205645738
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: ED70     Alopecia or hair loss Click to Show/Hide
The Studied Tissue     Skin from scalp
The Specified Disease     Alopecia [ICD-11:ED70]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000271661; Fold-change: 0.07822551; Z-score: 0.46051919
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: EK0Z     Contact dermatitis Click to Show/Hide
The Studied Tissue     Skin
The Specified Disease     Sensitive skin [ICD-11:EK0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.650262534; Fold-change: -0.083257535; Z-score: -0.361405331
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue Click to Show/Hide
                  ICD-11: FA00     Osteoarthritis Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Arthropathy [ICD-11:FA00-FA5Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.13125809; Fold-change: -0.140818661; Z-score: -0.71150722
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
The Studied Tissue     Synovial tissue
The Specified Disease     Osteoarthritis [ICD-11:FA00-FA0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.191253907; Fold-change: -0.184110559; Z-score: -0.586942528
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: FA20     Rheumatoid arthritis Click to Show/Hide
The Studied Tissue     Synovial tissue
The Specified Disease     Rheumatoid arthritis [ICD-11:FA20]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.000901866; Fold-change: -0.610158756; Z-score: -2.456330803
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: FA24     Juvenile idiopathic arthritis Click to Show/Hide
The Studied Tissue     Peripheral blood
The Specified Disease     Juvenile idiopathic arthritis [ICD-11:FA24]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.317992836; Fold-change: -0.017028676; Z-score: -0.057483745
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: FA92     Inflammatory spondyloarthritis Click to Show/Hide
The Studied Tissue     Pheripheral blood
The Specified Disease     Ankylosing spondylitis [ICD-11:FA92.0Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.614383266; Fold-change: -0.072413491; Z-score: -0.501336957
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: FB83     Low bone mass disorder Click to Show/Hide
The Studied Tissue     Bone marrow
The Specified Disease     Osteoporosis [ICD-11:FB83.1]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.817327158; Fold-change: 0.064669805; Z-score: 0.405652523
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 16 Disease of the genitourinary system Click to Show/Hide
                  ICD-11: GA10     Endometriosis Click to Show/Hide
The Studied Tissue     Endometrium tissue
The Specified Disease     Endometriosis [ICD-11:GA10]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.201297158; Fold-change: -0.079415784; Z-score: -0.343317108
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: GC00     Cystitis Click to Show/Hide
The Studied Tissue     Bladder tissue
The Specified Disease     Interstitial cystitis [ICD-11:GC00.3]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.186249406; Fold-change: -0.17671176; Z-score: -0.772895705
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 19 Certain condition originating in the perinatal period Click to Show/Hide
                  ICD-11: KA21     Short gestation disorder Click to Show/Hide
The Studied Tissue     Myometrium
The Specified Disease     Preterm birth [ICD-11:KA21.4Z]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.521953988; Fold-change: -0.01380645; Z-score: -0.028163969
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
      ICD Disease Classification 20 Developmental anomaly Click to Show/Hide
                  ICD-11: LD2C     Overgrowth syndrome Click to Show/Hide
The Studied Tissue     Adipose tissue
The Specified Disease     Simpson golabi behmel syndrome [ICD-11:LD2C]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.682429096; Fold-change: 0.022986834; Z-score: 0.0761005
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
                  ICD-11: LD2D     Phakomatoses/hamartoneoplastic syndrome Click to Show/Hide
The Studied Tissue     Perituberal tissue
The Specified Disease     Tuberous sclerosis complex [ICD-11:LD2D.2]
The Expression Level of Disease Section Compare with the Healthy Individual Tissue     p-value: 0.079901178; Fold-change: 0.354805458; Z-score: 1.813963922
Target expression in the diseased tissue of patients
Target expression in the normal tissue of healthy individuals
Boxplot of Target Disease-specific Protein Abundances Click to View the Clearer Original Diagram
References
1 Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. J Gen Virol. 2017 May;98(5):946-954.
2 ClinicalTrials.gov (NCT04379271) A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19). U.S. National Institutes of Health.
3 ClinicalTrials.gov (NCT04361214) Leflunomide in Mild COVID-19 Patients. U.S. National Institutes of Health.
4 IMU-838 Targeting DHODH
5 On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w.

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