Target Information
Target General Infomation | Top | ||||
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Target ID |
T99884
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Target Name |
HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway)
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Target Status |
Target in Phase 3 Trial
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[1] | |||
Disease | [+] 1 Target-related Diseases | + | |||
1 | COVID-19 [ICD-11: 1D6Y] |
Drugs and Modes of Action | Top | ||||
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Drugs in Phase 3 Trial | [+] 5 Drugs in Phase 3 Trial | + | |||
1 | Hydroxychloroquine | Drug Info | Phase 3 Trial | COVID-19 | [2], [3] |
2 | Darunavir + ritonavir + oseltamivir + hydroxychloroquine | Drug Info | Phase 3 Trial | COVID-19 | [4] |
3 | Oseltamivir + hydroxychloroquine | Drug Info | Phase 3 Trial | COVID-19 | [4] |
4 | Azithromycin + hydroxychloroquine | Drug Info | Phase 3 Trial | COVID-19 | [4] |
5 | Darunavir + ritonavir + favipiravir + hydroxychloroquine | Drug Info | Phase 3 Trial | COVID-19 | [4] |
Mode of Action | [+] 1 Modes of Action | + | |||
Inhibitor | [+] 5 Inhibitor drugs | + | |||
1 | Azithromycin + hydroxychloroquine | Drug Info | [1], [5] | ||
2 | Darunavir + ritonavir + favipiravir + hydroxychloroquine | Drug Info | [1], [5] | ||
3 | Darunavir + ritonavir + oseltamivir + hydroxychloroquine | Drug Info | [1], [5] | ||
4 | Hydroxychloroquine | Drug Info | [1], [5] | ||
5 | Oseltamivir + hydroxychloroquine | Drug Info | [1], [5] |
References | Top | ||||
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1 | Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. | ||||
2 | ClinicalTrials.gov (NCT04341727) Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection (WU352). U.S. National Institutes of Health. | ||||
3 | Covid-19: US gives emergency approval to hydroxychloroquine despite lack of evidence. BMJ 2020. April. 01; 369:m1335 | ||||
4 | ClinicalTrials.gov (NCT04321278) Safety and Efficacy of Hydroxychloroquine Associated With Azithromycin in SARS-CoV2 Virus (Coalition Covid-19 Brasil II). U.S. National Institutes of Health. | ||||
5 | Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know. Ann Intern Med. 2020 Mar 31. |
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