Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D00LHN | ||||||||||
| Drug Name | Sulfonylurea | ||||||||||
| Drug Resistance Mutations | |||||||||||
| Target Name | ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) | Target Info | |||||||||
| Gene Name | KCNJ11 | ||||||||||
| Uniprot ID | KCJ11_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT LASARGPLRKRSVPMAKAKPKFSISPDSLS [Homo sapiens] |
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| Targeted Disease | Diabetes mellitus | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Permanent neonatal diabetes mellitus due to KCNJ11 mutation in a Portuguese family: transition from insulin to oral sulfonylureas. J Pediatr Endocrinol Metab. 2012;25(3-4):367-70. | ||||||||||
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