Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D02OZK | ||||||||||
| Drug Name | Obatoclax | ||||||||||
| Synonyms | CHEMBL408194; UNII-QN4128B52A; QN4128B52A; SCHEMBL631676; SCHEMBL16340850; BDBM50376902; ZINC136873052; DB12191; NCGC00387855-01; BRD-K15600710-066-01-7 | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Company | Cephalon | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | SFV Envelope glycoprotein 1 (E1) | Target Info | |||||||||
| Gene Name | E1 | ||||||||||
| Uniprot ID | Q87046_SFV | ||||||||||
| Species | Semliki forest virus (SFV) | ||||||||||
| Reference Sequence |
YEHSTVMPNVVGFPYKAHIERPGYSPLTLQMQVVETSLEPTLNLEYITCEYKTVVPSPYV KCCGSSECSTKEKPDYQCKVYTGVYPFMWGGAYCFCDSENTQLSEAYVDRSDVCKHDHAS AYKAHTASLKAKVRVMYGNVNQTVDVYVNGDHAVTIGGTQFIFGPLSSAWTPFDNKIVVY KDEVFNQDFPPYGSGQPGRFGDIQSRTVESNDLYANTALKLARPSPGTVHVPYTQTPSGF KYWLKEKGTALNTKAPFGCQIKTNPVRAMNCAVGNIPVSMNLPDSAFTRIVEAPTITDLT CTVATCTHSSDFGGVLTLTYKTDKNGDCSVHSHSNVATLQEATAKVKTAGKVTLHFSTAS ASPSFVVSLCSAKATCSASCEPPKDHIVPYAASHSNVVFPDMSGTALSWVQKISGGLGAF AIGAILVLVVVTCIGLRR [Semliki forest virus (SFV)] |
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| Targeted Disease | Mosquito borne viral fever | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments. Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02227-16. | ||||||||||
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