Resistance mutation info of drug
| Drug General Information | ||||||||||||||||
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| Drug ID | D03TFJ | |||||||||||||||
| Drug Name | Benzimidazole | |||||||||||||||
| Synonyms | BENZIMIDAZOLE; 51-17-2; 1H-Benzimidazole; 1H-Benzo[d]imidazole; 1,3-Benzodiazole; Benzoimidazole; o-Benzimidazole; 3-Azaindole; Benziminazole; Benzoglyoxaline; Azindole; 1,3-Diazaindene; 1H-Benzoimidazole; N,N'-Methenyl-o-phenylenediamine; NSC 759; Benzimidazol; 1H-1,3-benzodiazole; BZI; UNII-E24GX49LD8; CCRIS 5967; Benzimidazole, 98%; CHEBI:41275; HSDB 2797; EINECS 200-081-4; BRN 0109682; AI3-03737; E24GX49LD8; HYZJCKYKOHLVJF-UHFFFAOYSA-N; DSSTox_CID_4573; DSSTox_RID_77454; DSSTox_GSID_24573; F3366-5347; CAS-51-17-2; bezimidazole | |||||||||||||||
| Drug Type | Small molecular drug | |||||||||||||||
| Structure |
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| Drug Resistance Mutations | ||||||||||||||||
| Target Name | HCMV Tripartite terminase subunit 1 (UL56) | Target Info | ||||||||||||||
| Gene Name | UL56 | |||||||||||||||
| Uniprot ID | TRM1_HCMVA | |||||||||||||||
| Species | Human cytomegalovirus | |||||||||||||||
| Reference Sequence |
MEMNLLQKLCVVCSKCNEYAMELECLKYCDPNVLLAESTPFKRNAAAIVYLYRKIYPEVV AQNRTQSSLLTLYLEMLLKALHEDTALLDRALMAYSRQPDRAAFYRTVLRLDRCDRHHTV ELQFTDNVRFSVSLATLNDIERFLCKMNYVYGILAPEAGLEVCAQLLELLRRLCGISPVA RQEVYVEGTTCAQCYEELTIIPNQGRSLNKRLQGLLCNHIAVHRPSSQSDVNIQTVEQDL LDLTTRIPHLAGVLSALKSLFSSSSAYHSYIQEAEEALREYNLFTDIPERIYSLSDFTYW SRTSEVIVKRVGITIQQLNVYHQLCRALMNGISRHLYGEDVEDIFVLGEKALDGEERMFV GSVFAAPNRIIDLITSLSIQAFEDNPVFNKLHESNEMYTKIKHILEEIRRPLPDGTGGDG PEGEAIHLRGREAMSGTGTTLMTASNSSNSSTHSQRNNGGGGRARGGGKKVVGGGVNGQD GDGSENGLRVRNCDEHEALDLVDARSRIHNVTREVNVRKRAYLQKVSEVGYGKVIRCIKT QERLTSKLIDVNLVGPLCLDFISKLMNGFLYRSQYHQDQDVVDVGDQFTYDEHLYVVNNL IHKSLPVESLPLLGQQIYELCNGPLFTHCTDRYPLSHNVDMAYACDNAGVLPHVKDDLVK CAEGTVYPSEWMVVKYMGFFNFSDCQDLNVLQKEMWMHVRELVLSVALYNETFGKQLSIA CLRDELHPDRDVILTYNKEWPLLLRHEGSLYKSKDLYLLLYRHLSRPDESGDVPTAPVAK PSTLTAAAAVSGVFREPDRPWLPSPYPSSSTAGVSRRVRATRKRPRRASSLLDLARDEHG IQDLVPGSLR [Human cytomegalovirus] |
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| Targeted Disease | Cytomegalovirus infection | |||||||||||||||
| Drug Resistance Mutations |
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| Target Name | HCMV Tripartite terminase subunit 1 + Tripartite terminase subunit 3 (UL56 + UL89) | Target Info | ||||||||||||||
| Gene Name | UL56 + UL89 | |||||||||||||||
| Uniprot ID | TRM1_HCMVM + TRM3_HCMVA | |||||||||||||||
| Species | Human cytomegalovirus | |||||||||||||||
| Reference Sequence |
MEMNLLQKLCVVCSKCNEYAMELECLKYCDPNVLLAESTPFKRNAAAIVYLYRKIYPEVV AQNRTQSSLLTLYLEMLLKALHEDTALLDRALMAYSRQPDRAAFYRTVLRLDRCDRHHTV ELQFTDNVRFSVSLATLNDIERFLCKMNYVYGILAPEAGLEVCAQLLELLRRLCGISPVA RQEVYVEGTTCAQCYEELTIIPNQGRSLNKRLQGLLCNHIAVHRPSSQSDVNIQTVEQDL LDLTTRIPHLAGVLSALKSLFSSSSAYHSYIQEAEEALREYNLFTDIPERIYSLSDFTYW SRTSEVIVKRVGITIQQLNVYHQLCRALMNGISRHLYGEDVEDIFVLGEKALDGEERMFV GSVFAAPNRIIDLITSLSIQAFEDNPVFNKLHESNEMYTKIKHILEEIRRPLPDGTGGDG PEGEVIHLRGREAMSGTGTTLMTASNSSNSSTHSQRNNGGGGRARGGGKKAVGGGANGQD GDGSENGLRVRNCDEHEALDLVDARSRIHNVTREVNVRKRAYLQKVSEVGYGKVIRCIKT QERLTSKLIDVNLVGPLCLDFISKLMNGFLYRSQYHQDQDVVDVGNQFTYDEHLYVVNNL IHKSLPVESLPLLGQQIYELCNGPLFTHCTDRYPLSHNVDMAYACDNAGVLPHVKDDLVK CAEGTVYPSEWMVVKYMGFFNFSDCQDLNVLQKEMWMHVRELVLSVALYNETFGKQLSIA CLRDELHPDRDVILTYNKEWPLLLRHEGSLYKSKDLYLLLYRHLSRPDESGDVPTAPVAK PSTLTAAAAVSGAFREPDRPWLPSPYPSSSTAGVSRRVRATRKRPRRASSLLDLARDEHG IQDLVPGSLR; MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVATLCRKRYQMMHP ELGLAHSCNEAFLPLMAFCGRHRDYNSPEESQRELLFHERLKSALDKLTFRPCSEEQRAS YQKLDALTELYRDPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIF FIAVTKIPVLANRVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISF LLKHMIGISIGYVAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTAL FASCYNTNSIRGQNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDSTCF LTRLNNAPFDMLNVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFM PGAFMDEIIGGTNKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTT NRKASGTGVAAVGAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDE LRIAVEGNTNQAAAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVE QFISRFNSGYIKASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRI SDDLIIAVIMATYLCDDIHAIRFRVS [Human cytomegalovirus] |
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| Targeted Disease | Cytomegalovirus infection | |||||||||||||||
| Drug Resistance Mutations |
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| Target Name | HCMV Tripartite terminase subunit 3 (UL89) | Target Info | ||||||||||||||
| Gene Name | UL89 | |||||||||||||||
| Uniprot ID | TRM3_HCMVA | |||||||||||||||
| Species | Human cytomegalovirus | |||||||||||||||
| Reference Sequence |
MLRGDSAAKIQERYAELQKRKSHPTSCISTAFTNVATLCRKRYQMMHPELGLAHSCNEAF LPLMAFCGRHRDYNSPEESQRELLFHERLKSALDKLTFRPCSEEQRASYQKLDALTELYR DPQFQQINNFMTDFKKWLDGGFSTAVEGDAKAIRLEPFQKNLLIHVIFFIAVTKIPVLAN RVLQYLIHAFQIDFLSQTSIDIFKQKATVFLVPRRHGKTWFIIPIISFLLKHMIGISIGY VAHQKHVSQFVLKEVEFRCRHTFARDYVVENKDNVISIDHRGAKSTALFASCYNTNSIRG QNFHLLLVDEAHFIKKEAFNTILGFLAQNTTKIIFISSTNTTSDSTCFLTRLNNAPFDML NVVSYVCEEHLHSFTEKGDATACPCYRLHKPTFISLNSQVRKTANMFMPGAFMDEIIGGT NKISQNTVLITDQSREEFDILRYSTLNTNAYDYFGKTLYVYLDPAFTTNRKASGTGVAAV GAYRHQFLIYGLEHFFLRDLSESSEVAIAECAAHMIISVLSLHPYLDELRIAVEGNTNQA AAVRIACLIRQSVQSSTLIRVLFYHTPDQNHIEQPFYLMGRDKALAVEQFISRFNSGYIK ASQELVSYTIKLSHDPIEYLLEQIQNLHRVTLAEGTTARYSAKRQNRISDDLIIAVIMAT YLCDDIHAIRFRVS [Human cytomegalovirus] |
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| Targeted Disease | Cytomegalovirus infection | |||||||||||||||
| Drug Resistance Mutations |
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| References | ||||||||||||||||
| REF 1 | Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56. | |||||||||||||||
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