Drug General Information
Drug ID D03UVS
Drug Name Gemcitabine
Synonyms Gemcitabine hydrochloride; DDFC; DFdC; DFdCyd; Folfugem; GEO; Gamcitabine; GemLip; Gemcel; Gemcin; Gemcitabina; Gemcitabinum; Gemtro; Gemzar; Zefei; Gemcitabine HCl; Gemcitabine stereoisomer; LY 188011; LY188011; Gemcitabina [INN-Spanish]; Gemcitabinum [INN-Latin]; Gemzar (TN); Gemzar (hydrochloride); Inno-D07001; LY-188011; Gemcitabine (USAN/INN)
Drug Type Small molecular drug
Therapeutic Class Anticancer Agents
Company Eli Lilly
Structure D03UVS
Drug Resistance Mutations
Target Name Deoxycytidine kinase (DCK) Target Info
Gene Name DCK
Uniprot ID DCK_HUMAN
Species Homo sapiens
Reference Sequence MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
DFKDKYESLVEKVKEFLSTL [Homo sapiens]
Targeted Disease Gastric cancer
Drug Resistance Mutations
Mutation info Missense: E197K [1]
References
REF 1 Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.Biochem Biophys Res Commun.2015 Sep 4;464(4):1084-9.

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