Drug General Information
Drug ID	D03WHC
Drug Name	Nnrti
Drug Resistance Mutations
Target Name	HIV Non-Nucleoside reverse transcriptase				Target Info
Uniprot ID	POL_HV1B1(600-1159)
Species	Human immunodeficiency virus type 1 (HIV-1)
Reference Sequence	PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKIL [Human immunodeficiency virus type 1 (H IV-1)]
Targeted Disease	HIV infection
Drug Resistance Mutations	Mutation info Missense: G190S [1] Mutation Frequency 8 out of 58 samples
	Mutation info Missense: H221Y [1] Mutation Frequency 9 out of 58 samples
	Mutation info Missense: K101E [1] Mutation Frequency 5 out of 58 samples
	Mutation info Missense: K103N [1] Mutation Frequency 14 out of 58 samples
	Mutation info Missense: V108I [1] Mutation Frequency 4 out of 58 samples
	Mutation info Missense: Y181C [1] Mutation Frequency 18 out of 58 samples
References
REF 1	Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clin... Open Forum Infect Dis. 2016 Aug 24;3(3):ofw154.

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