Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D04GSV | ||||||||||
| Drug Name | TRICIRIBINE | ||||||||||
| Synonyms | NSC154020; Akt Inhibitor V, Triciribine; MLS002702033; Akt/PKB Signaling Inhibitor-2; NSC-154020; TCN; Akt inhibitor V; AC1Q7CGY; AC1L6DVE; tricyclic nucleoside (TCN); SCHEMBL61269; GTPL5920; CHEMBL1892348; CHEBI:91697; HMS3268N05; HMS3654C06; HMS3229A09; HSCI1_000386; CCG-206732; 5-methyl-1-pentofuranosyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine; SMR001565606; SC-89664; NCI60_001091; Akt/protein kinase B signaling inhibitor-2; BRD-A42649439-001-01-0; BRD-A42649439-001-02-8; 1,5,6,8-Pentaazaacennaphthylen-3-amine, 1,5-dih | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | HIV Negative factor (nef) | Target Info | |||||||||
| Gene Name | nef | ||||||||||
| Uniprot ID | NEF_HV1A2 | ||||||||||
| Species | Human immunodeficiency virus type 1 (HIV-1) | ||||||||||
| Reference Sequence |
MGGKWSKRSMGGWSAIRERMRRAEPRAEPAADGVGAVSRDLEKHGAITSSNTAATNADCA WLEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYH TQGYFPDWQNYTPGPGIRYPLTFGWCFKLVPVEPEKVEEANEGENNSLLHPMSLHGMEDA EKEVLVWRFDSKLAFHHMARELHPEYYKDC [Human immunodeficiency virus type 1 (HIV-1)] |
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| Targeted Disease | HIV infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.Antimicrob Agents Chemother.2010 Apr;54(4):1512-9. | ||||||||||
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