Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0A2ZX | ||||||||||
| Drug Name | Metronidazole | ||||||||||
| Synonyms | APMN; Acromona; Anagiardil; Arilin; Atrivyl; Bexon; CONT; Clont; Danizol; Deflamon; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flegyl; Florazole; Fossyol; Giatricol; Gineflavir; Giniflavir; Klion; Klont; Meronidal; Methronidazole; Metric; MetroCream; MetroGel; MetroLotion; Metrodzhil; Metrogyl; Metrolag; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazolo; Metronidazolum; Metrotop; Metrozine; Metryl; Mexibol; Monagyl; Monasin; NIDA; Nalox; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; Rathimed; Rosased; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Trichocide; Trichomol; Trichopal; Trichopol; Tricocet; Tricom; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vandazole; Vertisal; Wagitran; Zadstat; Zidoval; Flagyl Er; Ginefla vir; METRONIDAZOLE USP; Metro Cream; Metro Gel; Metronidazole Monohydrochloride; Metronidazole Phosphoester; Metronidazole in Plastic Container; Metronidazolo [DCIT]; Tricho cordes; Trichomonacid pharmachim; Tricowas B; Bayer 5360; Flagyl 375; M0924; Metric 21; RP 8823; SC 10295; Anabact (TN); Apo-Metronidazole; Deflamon-wirkstoff; Flagyl (TN); IDR-90105; METRO I.V; MetroGel (TN); MetroGel-Vaginal; Metronidazol [INN-Spanish]; Metronidazolum [INN-Latin]; Mexibol (silanes); Neo-Tric; Noritate (TN); RP-8823; Rozex (TN); Tricho-gynaedron; ZERO/004064; CB-01-14 MMX; FLAGYL I.V. RTU IN PLASTIC CONTAINER; Flagyl I.V.; Flagyl I.V. RTU; Metro I.V.; Metro I.V. In Plastic Container; Metrogel-vaginal (TN); Metronidazole (JP15/USP/INN); Metronidazole [USAN:INN:BAN:JAN]; Methyl-5-nitroimidazole-1-ethanol; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; 2-Methyl-5-nitro-1-imidazoleethanol; 2-Methyl-5-nitroimidazole-1-ethanol; MNZ | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Therapeutic Class | Antiinfective Agents | ||||||||||
| Company | Pfizer Pharmaceuticals | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Bacterial Diaminopimelate epimerase (dapF) | Target Info | |||||||||
| Gene Name | dapF | ||||||||||
| Uniprot ID | DAPF_HELPY | ||||||||||
| Species | Helicobacter pylori | ||||||||||
| Reference Sequence |
MVFYKYSGSGNDFLIVQSFKKKDFSNLAKQVCHRHEGFGADGLVVVLPSKDYDYEWDFYN SDGSKAGMCGNASRCVGLFAYQHAIASKNHVFLAGKREISICIEEPNIIESNLGNYKILD VIPALRCEKFFSSGSVLEHIPTFYLIDTGVPHLVGFVENKEGLNSLNTLELRALRHEFNA NINIAFIENKETIFLQTYERGVEDFTLACGTGMAAVFIAARIFYNTPKKAALIPKSNESL ELSLKNDGIFYKGAVRYIGMSVLGMRVFENGCF [Helicobacter pylori] |
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| Targeted Disease | Helicobacter pylori infection | ||||||||||
| Drug Resistance Mutations |
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| Target Name | Bacterial Thioredoxin (trxA) | Target Info | |||||||||
| Gene Name | trxA | ||||||||||
| Uniprot ID | THIO_HELPY | ||||||||||
| Species | Helicobacter pylori | ||||||||||
| Reference Sequence |
MSHYIELTEENFESTIKKGVALVDFWAPWCGPCKMLSPVIDELASEYEGKAKICKVNTDE QEELSAKFGIRSIPTLLFTKDGEVVHQLVGVQTKVALKEQLNKLLG [Helicobacter pylori] |
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| Targeted Disease | Helicobacter pylori infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Clarithromycin-Based Triple Therapy is Still Useful as an Initial Treatment for Helicobacter pylori Infection in the Dominican Republic.Am J Trop Med Hyg.2017 May;96(5):1050-1059. | ||||||||||
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