Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0F5JZ | ||||||||||
| Drug Name | PLX-4720 | ||||||||||
| Synonyms | PLX 4720; PLX4720 (BRAF inhibitor) | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) | Target Info | |||||||||
| Gene Name | MAP2K1 | ||||||||||
| Uniprot ID | MP2K1_HUMAN | ||||||||||
| Species | Homo sapiens | ||||||||||
| Reference Sequence |
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV [Homo sapiens] |
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| Targeted Disease | Skin cancer | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20411-6. | ||||||||||
| REF 2 | Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol. 2011 Aug 1;29(22):3085-96. | ||||||||||
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