Resistance mutation info of drug
| Drug General Information | |||||||||||
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| Drug ID | D0K7NQ | ||||||||||
| Drug Name | Colistin | ||||||||||
| Synonyms | Colistin sulphate; Polymyxin E; Colistin sulfate, nonsterile; Polymyxin E. Sulfate; Coly-Mycin M Parenteral (TN) | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Therapeutic Class | Antibiotics | ||||||||||
| Company | Parkdale Pharmaceuticals | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Bacterial Two-component response regulator (PhoP) | Target Info | |||||||||
| Gene Name | PhoP | ||||||||||
| Uniprot ID | Q9I4F9_PSEAE | ||||||||||
| Species | Pseudomonas aeruginosa | ||||||||||
| Reference Sequence |
MKLLVVEDEALLRHHLYTRLGEQGHVVDAVPDAEEALYRVSEYHHDLAVIDLGLPGMSGL DLIRELRSQGKSFPILILTARGNWQDKVEGLAAGADDYVVKPFQFEELEARLNALLRRSS GFVQSTIEAGPLVLDLNRKQALVEEQPVALTAYEYRILEYLMRHHQQVVAKERLMEQLYP DDEERDANVIEVLVGRLRRKLEACGGFKPIDTVRGQGYLFTERCR [Pseudomonas a eruginosa] |
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| Targeted Disease | Pseudomonas infection | ||||||||||
| Drug Resistance Mutations |
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| Target Name | Bacterial Two-component sensor (PhoQ) | Target Info | |||||||||
| Gene Name | PhoQ | ||||||||||
| Uniprot ID | Q9I4F8_PSEAE | ||||||||||
| Species | Pseudomonas aeruginosa | ||||||||||
| Reference Sequence |
MIRSLRIRLMLGAAALAVLFMLALLPALQRAFGIALENTIEQRLAADVATLVSAARVEKG RLVMPEHLPVEEFNLPEAKVLGYIYDQNGDLLWRSTSAADESINYTPRYDGRGNEFHTTR DAKGEEFFVFDVEIDLLRGKQAAYSIVTMQSVSEFESLLKGFREQLYLWLGGALLVLLGL LWLGLTWGFRAMRGLSSELDQIESGERESLSEEHPRELLRLTHSLNRLLRSEHKQRERYR HSLGDLAHSLKTPLAVLQGVGDQLAEEPGNREQVRVLQGQIERMSQQIGYQLQRASLRKS GLVRHREQLAPLVETLCDALDKVYRDKRVSLQRDFSPSFSVPVERGALLELLGNLLENAY RLCLGRVRVGARLGPGYSELWVEDDGPGVPAEQRARIIRRGERADTQHPGQGIGLAVALD IIESYDGELSLDDSELGGACFRIRFATV [Pseudomonas aeruginosa] |
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| Targeted Disease | Pseudomonas infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. | ||||||||||
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