Resistance mutation info of drug
| Drug General Information | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Drug ID | D0L4JT | ||||||||||
| Drug Name | Sulfanilamide | ||||||||||
| Synonyms | AAS; AVC; Albexan; Albosal; Ambeside; Antistrept; Astreptine; Astrocid; Bactesid; Collomide; Colsulanyde; Copticide; Deseptyl; Desseptyl; Dipron; Ergaseptine; Gerison; Gombardol; Infepan; Lusil; Lysococcine; Neococcyl; Orgaseptine; PABS; Prontalbin; Prontylin; Proseptal; Proseptine; Pysococcine; SAN; Sanamid; Septanilam; Septolix; Septoplex; Septoplix; Solfanilamide; Stramid; Strepamide; Streptagol; Streptamid; Streptocid; Streptocide; Streptocidum; Streptocom; Streptol; Strepton; Streptopan; Streptrocide; Sulfanilamida; Sulfanilamidum; Sulfocidin; Therapol; Tolder; Prontosil I; Prontosil White; Pronzin Album; Rubiazol A; Septamide Album; Solfanilamide [DCIT]; Stopton Album; Streptocid album; Streptocide White; Sulfanilamide Vaginal Cream; Sulphanilamide Extra Pure; Sulphanilamide Gr; White streptocide; F 1162; Fourneau 1162; Ro13354; A-349; AVC (TN); Aromatic/heteroaromatic sulfonamide 2; F-1162; P-Aminobenzenesulfonylamide; P-Aminobenzensulfonamide; Streptocid (TN); Streptocide (VAN); Sulfanilamida [INN-Spanish]; Sulfanilamide (INN); Sulfanilamide [INN:DCF]; Sulfanilamidum [INN-Latin]; Aniline-p-sulfonic amide; I.C. 56; BENZENESULFONIC ACID,4-AMINO,AMIDE SULFANILAMIDE; N4,N4-Bis(2-bromoethyl)sulfanilamide; N(sup 4),N(sup 4)-Bis(2-bromoethyl)sulfanilamide; N(sup4),N(sup4)-Bis(2-bromoethyl)sulfanilamide; Benzenesulfonamide, 4-(bis(2-bromoethyl)amino)-(9CI); Sulfanilamide, N4,N4-bis(2-bromoethyl)-(8CI); 1162 F; 4-(Bis(2-bromoethyl)amino)benzenesulfonamide; 4-Aminobenzene-1-Sulfonamide; 4-Aminophenylsulfonamide; 4-Sulfamoylaniline; 4-[bis(2-bromoethyl)amino]benzenesulfonamide | ||||||||||
| Drug Type | Small molecular drug | ||||||||||
| Therapeutic Class | Antibiotics | ||||||||||
| Structure |
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| Drug Resistance Mutations | |||||||||||
| Target Name | Fungal Folic acid synthesis protein (fol1) | Target Info | |||||||||
| Gene Name | FOL1 | ||||||||||
| Uniprot ID | L0P7Z1_PNEJ8 | ||||||||||
| Species | Pneumocystis jiroveci | ||||||||||
| Reference Sequence |
MRFKSINLKIVPFYQICYFKSVTRIFFGRDIHSLKLNKDYDLIHIHSLTLKSIIGKNLWA QKLLQPVFLTLSFRKNTTFLENLDDLSYSIDYTIVYKEVYKLVESSEFQDLADLADKISE LVFSHKCKANWVKIKIETPKGNLFAGTGLQVVRRKDGIVEVDDQFFVKKLSLFTIIGMNP EEMINKQNIIINLILYKSPINLEDRNCSIINIYNIEKVLKEIVKHVESSSFKTIEALALS IARILCISHNIEKIKVNVEKPSALAFARSAGVEIVRSRSCFFSDDYINSKGPVDNDAIYI ALGSNLGNKVKFISDAIEKMSIRGIKVLKTSMLYESEPMYFKDQPVFYNAVCKVETSLNP KQLLDELKTIEKEFGRVKTIDKGPRCIDLDIIFFRRKIINSESLIVPHPQALERPFVLKP LCDISNDLVHPITGLPIVSYLKKIVNPGIKPVLPFLYKNRSINFSSEFYKAPTHIMAILN LTPDSFFDGGVHSYDSILMDVENFINAGATIIDIGGQSTRSGSHVVSIEEEISRVIPAIK YLLKVYPDILVSVDTFRSEVAEQAIKAGASLVNDISGGRYDPKMLNVVAKLKVPICIMHM RGDFLTMDNLTDYGTDIIKQITKELEELLVFAESSGIFRWNIILDPGLGFAKTSYQNIEL LRRFNELKSQHCFNGLPWLLGPSRKRFTGCLTGDVMPKDRIWGTAASVAASVLGGCDIIR VHDVYEMYKVSRTLDAIWKGVY [Pneumocystis jiroveci] |
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| Targeted Disease | Pneumocystis infection | ||||||||||
| Drug Resistance Mutations |
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| References | |||||||||||
| REF 1 | Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2004 Jul;48(7):2610-6. | ||||||||||
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