| Drug General Information |
| Drug ID |
D0P0HB
|
| Drug Name |
Ethionamide |
|
| Synonyms |
Aethionamidum; Aetina; Aetiva; Amidazin; Amidazine; Atina; Ethatyl; Ethimide; Ethina; Ethinamide; Ethionamidum; Ethioniamide; Ethylisothiamide; Ethyonomide; Etimid; Etiocidan; Etionamid; Etionamida; Etionamide; Etioniamid; Etionid; Etionizin; Etionizina; Etionizine; Fatoliamid; Iridocin; Iridozin; Isothin; Isotiamida; Itiocide; Nicotion; Nisotin; Nizotin; Rigenicid; Sertinon; Teberus; Thianid; Thianide; Thioamide; Thiomid; Thioniden; Tianid; Tiomid; Trecator; Trekator; Trescatyl; Trescazide; Tubenamide; Tubermin; Tuberoid; Tuberoson; Ethionamid prothionamid; Etionamide [DCIT]; Iridocin Bayer; Trecator SC; Wyeth Brand of Ethionamide; Bayer 5312; Bayer5312; E0695; TH 1314; Alpha-Ethylisonicotinic acid thioamide; Alpha-Ethylisonicotinoylthioamide; Alpha-Ethylisothionicotinamide; Alpha-Ethylthioisonicotinamide; Alpha-ethylt hioisonicotinamide; Ethina (VAN); Ethionamidum [INN-Latin]; Etionamida [INN-Spanish]; Tio-Mid; Trecator-SC; Alpha-Ethyl-thioisonicotinamide; Trecator-SC (TN); Ethionamide (JP15/USP/INN); Ethionamide [USAN:INN:BAN:JAN]; 2-ETHYL-4-PYRIDINECARBOTHIOAMIDE; 2-Ethyl-4-thioamidylpyridine; 2-Ethyl-4-thiocarbamoylpyridine; 2-Ethyl-thioisonicotinamide; 2-Ethylisonicotinic acid thioamide; 2-Ethylisonicotinic thioamide; 2-Ethylisonicotinothioamide; 2-Ethylisonicotinoylthioamide; 2-Ethylisothionicotinamide; 2-Ethylthioisonicotinamide; 2-e thylisothionicotinamide; 2-ethyl-4-aminothiocarbonylpyridine; 2-ethylisonicotinic acid thiomide; 2-ethylpyridine-4-carbothioamide; 2-ethylthioisonicotinamide, Trecator SC, Amidazine, Ethionamide; 3-Ethylisothionicotinamide |
| Drug Type |
Small molecular drug |
| Therapeutic Class |
Antituberculosis Agents |
| Structure |
|
| Drug Resistance Mutations |
| Target Name |
Bacterial Prodrug activator (EtaA) |
Target Info |
| Gene Name |
ethA |
| Uniprot ID |
ETHA_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MTEHLDVVIVGAGISGVSAAWHLQDRCPTKSYAILEKRESMGGTWDLFRYPGIRSDSDMY
TLGFRFRPWTGRQAIADGKPILEYVKSTAAMYGIDRHIRFHHKVISADWSTAENRWTVHI
QSHGTLSALTCEFLFLCSGYYNYDEGYSPRFAGSEDFVGPIIHPQHWPEDLDYDAKNIVV
IGSGATAVTLVPALADSGAKHVTMLQRSPTYIVSQPDRDGIAEKLNRWLPETMAYTAVRW
KNVLRQAAVYSACQKWPRRMRKMFLSLIQRQLPEGYDVRKHFGPHYNPWDQRLCLVPNGD
LFRAIRHGKVEVVTDTIERFTATGIRLNSGRELPADIIITATGLNLQLFGGATATIDGQQ
VDITTTMAYKGMMLSGIPNMAYTVGYTNASWTLKADLVSEFVCRLLNYMDDNGFDTVVVE
RPGSDVEERPFMEFTPGYVLRSLDELPKQGSRTPWRLNQNYLRDIRLIRRGKIDDEGLRF
AKRPAPVGV [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: A381P |
[1], [2] |
|
| Mutation info |
Missense: D58A |
[1], [2] |
|
| Mutation info |
Missense: G43C |
[1], [2] |
|
| Mutation info |
Missense: P51L |
[1], [2] |
|
| Mutation info |
Missense: T186K |
[1], [2] |
|
| Mutation info |
Missense: T342K |
[1], [2] |
|
| Mutation info |
Missense: E223K |
[2], [3] |
|
| Mutation info |
Missense: G385D |
[2], [3] |
|
| Mutation info |
Missense: G413D |
[2], [3] |
|
| Mutation info |
Missense: G43S |
[2], [3] |
|
| Mutation info |
Missense: I338S |
[2], [3] |
|
| Mutation info |
Missense: R463S |
[2], [3] |
|
| Mutation info |
Missense: T392A |
[2], [3] |
|
| Mutation info |
Frameshift: Plus 22 |
[1] |
|
| Mutation info |
Frameshift: Plus 270 |
[1] |
|
| Mutation info |
Missense: Y84D |
[1] |
|
| Mutation info |
Missense: D55A |
[3] |
|
| Mutation info |
Frameshift: Plus 113 |
[3] |
|
| Mutation info |
Frameshift: Plus 234 |
[3] |
|
| Mutation info |
Frameshift: Plus 256 |
[3] |
|
| Mutation info |
Frameshift: Plus 37 |
[3] |
|
| Mutation info |
Frameshift: Plus 430 |
[3] |
|
| Mutation info |
Frameshift: Plus 441 |
[3] |
|
| Mutation info |
Nonsense: Q246 STOP |
[3] |
|
| Target Name |
Bacterial Enoyl-[acyl-carrier-protein] reductase [NADH] (Inha) |
Target Info |
| Gene Name |
inhA |
| Uniprot ID |
INHA_MYCTU |
| Species |
Mycobacterium tuberculosis |
| Reference Sequence |
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL [Mycobacterium tuberculosis]
|
| Targeted Disease |
Tuberculosis |
| Drug Resistance Mutations |
| Mutation info |
Missense: S94A |
[4] |
|
| Mutation info |
Missense: I95P |
[5] |
| Mutation Frequency |
7 out of 14 isolates |
|
| References |
| REF 1 |
Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9677-82.
|
| REF 2 |
Bioinformatics of antimicrobial resistance in the age of molecular epidemiology. Curr Opin Microbiol. 2015 Oct;27:45-50.
|
| REF 3 |
ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2003 Dec;47(12):3799-805.
|
| REF 4 |
Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int J Tuberc Lung Dis. 2000 May;4(5):441-7.
|
| REF 5 |
New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains. Lancet. 1995 Aug 19;346(8973):502-3.
|
