Resistance mutation info of drug
| Drug General Information | ||||||||||||||||
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| Drug ID | D0R4EY | |||||||||||||||
| Drug Name | Boscalid | |||||||||||||||
| Synonyms | Boscalid; 188425-85-6; Nicobifen; Endura; 2-Chloro-N-(4'-chloro-[1,1'-biphenyl]-2-yl)nicotinamide; Emerald; Anilide; Cantus; Boscalid [ISO]; UNII-32MS8ZRD1V; 2-chloro-N-(4'-chlorobiphenyl-2-yl)nicotinamide; BAS 510F; 3-Pyridinecarboxamide, 2-chloro-N-(4'-chloro[1,1'-biphenyl]-2-yl)-; 32MS8ZRD1V; CHEBI:81822; 2-chloro-N-[2-(4-chlorophenyl)phenyl]pyridine-3-carboxamide; WYEMLYFITZORAB-UHFFFAOYSA-N; NCGC00163735-04; 3-Pyridinecarboxamide, 2-chloro-N-(4'-chloro(1,1'-biphenyl)-2-yl)-; HSDB 7499; AC1Q1HCS; AC1L4U3A; DSSTox_RID_79152 | |||||||||||||||
| Drug Type | Small molecular drug | |||||||||||||||
| Structure |
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| Drug Resistance Mutations | ||||||||||||||||
| Target Name | Fungal 3-ketosteroid reductase (erg27) | Target Info | ||||||||||||||
| Gene Name | erg27 | |||||||||||||||
| Uniprot ID | K0H656_BOTFU | |||||||||||||||
| Species | Botrytis cinerea | |||||||||||||||
| Reference Sequence |
MGLPPWETSESQTFALITGANSGLGFAIASRLIDEFLTSSDTPPTKHLILILCTRTPLKT RFTISRLRAHLRKLADYSEFATSHRAKAKSQGNVYRWQDTVARVHFLGVEVDLCDLKSVY ALTDRLVNGTVGSPDATTMDGLRLPDGSPGTATYSADVKQDRWALSQKEGSEGELRSWGW GLSGIRIPRLDVVVLNAGIGGWSGIDWPKAIWTVITDMTEAVTWPTYKLAEIGVITKPQL SSASSKQAKPSDDEAAQPLLDGESPEEPPLGATFCSNVFGHYVLAHELMPLLSRTASPSA TTSGRIIWVSSIEAQAQHFDEDDLQGLESRTPYESSKRLTDVLVLSRKLRAAGQASSSWF DCSDVRVENSKSEEEPAAKLIRPKMYVVQPGIFVSEIMPLNFVLVFIYRLISYLVRWMGS QWHTIKPYTAAVAPVWVALSPDDVLDNMDGAASKWGSATDASGKERVIRTEVPGWGWEGK TPKTIDTGERRKGRQRNAEPLTREAREDFEVLGVKCWTEMENLRKEWEGLLKVKK [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Two-component osmosensing histidine-kinase (bos1) | Target Info | ||||||||||||||
| Gene Name | bos1 | |||||||||||||||
| Uniprot ID | Q8X1E7_BOTFU | |||||||||||||||
| Species | Botrytis cinerea | |||||||||||||||
| Reference Sequence |
MEDSTIAHTTAILQTLALSSIDLPLTNVYGNKGIRLPGADTAEKLALERELAALVSRVQR LEARAITVNNQTLPDTPNELGAPSAFADVLTGAPSRASKSTTSRQQLVNSLLAAREAPTG GERPPKFTKLSDEELEALREHVDHQSKQLDSQKSELAGVHAQLFEQKQRQEQALNVLEVE RVAALERELKKHQQANEAFQKALREIGEIVTAVARGDLSKKVQIHSVEMDPEITTFKRVI NTMMDQLQIFSSEVSRVAREVGTEGILGGQAKISGVDGTWKELTDNVNVMAQNLTDQVRE IASVTTAVAHGDLTQKIERPAQGEILQLQQTINTMVDQLRTFAAEVTRVARDVGTEGILG GQAEIEGVQGMWNTLIVNVNAMANNLTTQVRDIAIVTTAVAKGDLTQKVQAECKGEIKQL KETINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTT QVREIAKVTTAVARGDLTKKIEVEVQGEIASLKDTINTMVDRLSTFAFEVSKVAREVGTD GTLGGQAQVDNVEGKWKDLTENVNTMARNLTTQVRGISTVTQAIANGDMSQKIEVAAAGE ILILKETINNMVDRLSIFSNEVQRVAKDVGVDGKMGGQADVAGIGGRWKEITTDVNTMAN NLTTQVRAFGDITNAATDGDFTKLITVEASGEMDELKRKINQMVYNLRDSIQRNTLAREA AEFANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVHNLANSLLTII DDILDLSKIEANRMIMEEIPYTLRGTVFNALKTLAVKANEKFLDLTYRVDSSVPDHVVGD SFRLRQVILNLVGNAIKFTEHGEVSLTIQKAEQDHCAPNEYAVEFCVSDTGIGIQADKLN LIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMRGDVWVKSQYGKGSSFYFTCTVRLAT SDISFIQKQLKPYQGHNVLFIDKGQTGHGKEIITMLTQLGLVPVVVDSEQHTILLGNGRT KEKIASTYDVIVVDSIESARKLRSIDEFKYIPIVLLAPVIHVSLKSALDLGITSYMTTPC LTIDLGNGMIPALENRAAPSLADNTKSFDILLAEDNIVNQRLAVKILEKYHHVVTVVGNG QEALDAIKEKRYDVILMDVQMPIMGGFEATAKIREYERSLGTQRTPIIALTAHAMLGDRE KCIQAQMDEYLSKPLKQNHLIQTILKCATLGGALLEKGREVRQSANEESPNSQNGPRGTQ HPASSPTPAHMRPAIEPRAYTTTGPINHGSAESPSLVTADAEDPLARLLMRAHSS [Bot rytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Cytochrome b (cytb) | Target Info | ||||||||||||||
| Gene Name | cytb | |||||||||||||||
| Uniprot ID | Q18ND9_BOTFU | |||||||||||||||
| Species | Botrytis cinerea | |||||||||||||||
| Reference Sequence |
MRIFKSHPLLKLVNSYMIDSPQPSNLSYLWNFGSLLAVCLVIQIITGVTLAMHYNPSVLE AFNSVEHIMRDVNNGWLIRYLHSNTASAFFFIVYLHIGRGLYYGSYRAPRTLVWTIGVVI FILMIVTAFLGYVLPYGQMSLWGATVITNLMSAVPWIGQDIVEFLWGGFSVNNATLNRFF ALHFVLPFVLAALALMHLIALHDSAGSGNPLGISGNYDRLAFAPYFLFKDLITIFLFIII LSIFVFFMPNVLGDSDNYIMANPMQTPPAIVPEWYLLPFYAILRSIPNKLLGVIAMLSAI LILLAMPFTDLSRSRGIQFRPLSKIAFYIFIANFLILMVLGAKHVESPYIEFGQISTVIY FAHFLIIVPFISLLENSLVELAVLTKEKPSR [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb) | Target Info | ||||||||||||||
| Gene Name | sdhb | |||||||||||||||
| Uniprot ID | Q3ZMH5_BOTFU | |||||||||||||||
| Species | Botrytis cinerea | |||||||||||||||
| Reference Sequence |
MAALRTGARSARAIFAASRPAFRTQMRTMASVDSSVPESPTVSPSRPVESASKTSTVKEP AADSESLIKTFNIYRWNPDEPTSKPRMQSYTLDLNKTGPMMLDALIRIKNEVDPTLTFRR SCREGICGSCAMNIDGVNTLACLCRIPRDAKHETKIYPLPHTYVVKDIVPDLTQFYKQYK SIKPYLQHTDPAPEGKEYLQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAIL LQSYRWLADSRDQKKEERKAALDNSMSLYRCHTILNCSRTCPKGLNPGLAIAEIKKEMAF [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| Target Name | Fungal Tubulin beta chain (tubA) | Target Info | ||||||||||||||
| Gene Name | tubA | |||||||||||||||
| Uniprot ID | TBB_BOTFU | |||||||||||||||
| Species | Botrytis cinerea | |||||||||||||||
| Reference Sequence |
MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGTSDLQLERMNVYFNEASGNKYV PRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVV RREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVV EPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCL RFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVTVPELTQQMYDPKNMM AASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRG LKMSSTFVGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS EYQQYQDASISEGEEEYEEEVPIEGEE [Botrytis cinerea] |
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| Drug Resistance Mutations |
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| References | ||||||||||||||||
| REF 1 | Independent Emergence of Resistance to Seven Chemical Classes of Fungicides in Botrytis cinerea.Phytopathology.2015 Apr;105(4):424-32. | |||||||||||||||
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