Drug General Information
Drug ID
D00EEL
Former ID
DAP001385
Drug Name
Gaboxadol
Synonyms
Gaboxadolum; Gaboxadolum [Latin]; LU 2030; Gaboxadol [USAN:INN]; Lu 02-030; MK-0928; Gaboxadol (USAN/INN); LU-2-030; Lu-02-030; Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate; 4,5,6,7-Tetrahydroisoxazole(5,4-c)pyridin-3-ol; 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
Drug Type
Small molecular drug
Indication Insomnia [ICD-11: 7A00-7A0Z] Approved [1], [2]
Therapeutic Class
Hypnotics and Sedatives
Company
Merck & Co
Structure
Download
2D MOL

3D MOL

Formula
C6H8N2O2
InChI
1S/C6H8N2O2/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9)
InChIKey
ZXRVKCBLGJOCEE-UHFFFAOYSA-N
CAS Number
CAS 64603-91-4
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) GABA(A) receptor delta (GABRD) Target Info Modulator [3]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4322).
REF 2 Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem. J Sleep Res. 2009 Dec;18(4):387-96.
REF 3 Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6.

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