Drug General Information
Drug ID
D00PEH
Former ID
DCL000792
Drug Name
Eltrombopag
Synonyms
Eltrombopag [INN]; SB 497115; SB497115; SB-497115; [1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-[1-(3,4-dime; Thylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-(9CI); (E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid
Drug Type
Small molecular drug
Indication Thrombocytopenia [ICD-11: 3B64] Approved [1], [2]
Idiopathic thrombocytopenic purpura [ICD-11: 3B64.10; ICD-10: D69.3; ICD-9: 287.31] Phase 3 [1], [3]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C25H22N4O4
InChI
1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey
XDXWLKQMMKQXPV-QYQHSDTDSA-N
CAS Number
CAS 443130-00-5
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Thrombopoietin receptor (MPL) Target Info Agonist [3]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6961).
REF 2 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
REF 3 Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.

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