Drug General Information
Drug ID
D00YZD
Former ID
DNCL002987
Drug Name
Dolutegravir
Synonyms
1051375-16-6; GSK1349572; Tivicay; S/GSK1349572; Dolutegravir (GSK1349572); S-349572; GSK-1349572; GSK 1349572; UNII-DKO1W9H7M1; (4r,12as)-N-(2,4-Difluorobenzyl)-7-Hydroxy-4-Methyl-6,8-Dioxo-3,4,6,8,12,12a-Hexahydro-2h-Pyrido[1',2':4,5]pyrazino[2,1-B][1,3]oxazine-9-Carboxamide; CHEBI:76010; DKO1W9H7M1; Tivicay (TN); (4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide; Dolutegravir Sodium (
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] Approved [1], [2]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C20H19F2N3O5
InChI
1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
InChIKey
RHWKPHLQXYSBKR-BMIGLBTASA-N
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
J05AX12
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Human immunodeficiency virus Integrase (HIV IN) Target Info Modulator [2], [3]
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7365).
REF 2 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
REF 3 Clinical pipeline report, company report or official report of Shionogi (2011).

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