Drug Information

Drug General Information

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Drug ID

D01LCC

Former ID

DND000006

Drug Name

PF-4217903

Synonyms

2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol; PF-04217903; 956905-27-4; PF04217903; PF 04217903; UNII-CYJ9ATV1IJ; CYJ9ATV1IJ; 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol; CHEMBL2001019; 1159490-85-3; aka PF-04217903; C19H16N8O; 2-[4-(3-Quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-pyrazol-1-yl]-ethanol; 2-(4-(1-(Quinolin-6-ylmethyl)-1H-(1,2,3)triazolo(4,5-b)pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol; 3zxz; PDMUGYOXRHVNMO-UHFFFAOYSA-N; PF-04217903

Drug Type

Small molecular drug

Indication

Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229]

Phase 1

[1]

Company

Pfizer

Structure

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2D MOL

3D MOL

Formula

C19H16N8O

Canonical SMILES

C1=CC2=C(C=CC(=C2)CN3C4=NC(=CN=C4N=N3)C5=CN(N=C5)CCO)N=C1

InChI

1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

InChIKey

PDMUGYOXRHVNMO-UHFFFAOYSA-N

CAS Number

CAS 956905-27-4

PubChem Compound ID

17754438

PubChem Substance ID

29212271, 54248092, 99436977, 103905666, 124756993, 125011823, 125163798, 131480678, 134964423, 135653868, 135685260, 135685261, 135685280, 136340178, 136367293, 136920363, 137276005, 140816092, 143499148, 143499149, 152235007, 152237698, 152258340, 160647178, 162011939, 162037429, 162202551, 163312449, 163345958, 163907943, 164045116, 164764187, 170484567, 172113563, 177748688, 186022475, 198969694, 223402404, 223617434, 223705036, 224378934, 226471317, 247681667, 251963200, 252216038, 252216039, 252451594, 252543331

ChEBI ID

CHEBI:91425

Target and Pathway

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Target(s)

Proto-oncogene c-Met (MET)

Target Info

Inhibitor

[2]

KEGG Pathway

Ras signaling pathway

Rap1 signaling pathway