Drug General Information
Drug ID
D04FKX
Former ID
DNCL002410
Drug Name
D-3263
Synonyms
TDBTU; 125700-69-8; N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate; O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; MFCD00077730; AK170015; o-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-n,n,n',n'-tetramethyluroniumtetrafluoroborate; 1,1,3,3-tetramethyl-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)uronium tetrafluoroborate; TDBTU; N,N,N',N'-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate
Drug Type
Small molecular drug
Indication Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] Phase 1 [1]
Company
Dendreon
Structure
Download
2D MOL

3D MOL

Formula
C12H16BF4N5O2
Canonical SMILES
[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2=CC=CC=C2N=N1
InChI
1S/C12H16N5O2.BF4/c1-15(2)12(16(3)4)19-17-11(18)9-7-5-6-8-10(9)13-14-17;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
InChIKey
FOBCPCIJLQTYBT-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Long transient receptor potential channel 8 (TRPM8) Target Info Modulator [2]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
REF 1 ClinicalTrials.gov (NCT00839631) Dose Escalation Study of EC D-3263 HCl in Advanced Solid Tumors. U.S. National Institutes of Health.
REF 2 Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.

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