Drug General Information
Drug ID
Former ID
Drug Name
BMS-734016; MDX-010; MDX-101; Yervoy (TN)
Drug Type
Monoclonal antibody
Indication Melanoma [ICD-11: 2C30] Approved [1], [2], [3]
Bristol-Myers Squibb
CAS Number
CAS 477202-00-9
SuperDrug ATC ID
Target and Pathway
Target(s) Cytotoxic T-lymphocyte protein 4 (CTLA-4) Target Info . [2]
KEGG Pathway Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Autoimmune thyroid disease
Rheumatoid arthritis
Pathway Interaction Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Reactome CTLA4 inhibitory signaling
WikiPathways Vitamin D Receptor Pathway
T-Cell Receptor and Co-stimulatory Signaling
Allograft Rejection
Costimulation by the CD28 family
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6888).
REF 2 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
REF 3 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.

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