Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07OJZ
|
||||
| Former ID |
DNCL003627
|
||||
| Drug Name |
INCB28060
|
||||
| Synonyms |
capmatinib; 1029712-80-8; INCB28060; INC-280; INC280; UNII-TY34L4F9OZ; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide; INC28060; INCB-28060; INCB28060(Capmatinib); NVP-INC280; TY34L4F9OZ; Capmatinib (INCB28060); INCB 28060; 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide; BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-; C23H17FN6O
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Hepatocellular carcinoma [ICD-11: 2C12.02; ICD-10: C22.0; ICD-9: 155] | Phase 2 | [1] | ||
| Non-small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162] | Phase 2 | [2] | |||
| Recurrent glioblastoma [ICD-11: 2A00.00; ICD-10: C71] | Phase 1 | [2], [3] | |||
| Company |
Incyte
|
||||
| Structure |
 |
Download2D MOL |
|||
| Formula |
C23H17FN6O
|
||||
| InChI |
1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
|
||||
| InChIKey |
LIOLIMKSCNQPLV-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
56473134, 81021450, 140970141, 144116075, 152159599, 162011567, 162205174, 163643087, 163763208, 165246955, 174006562, 174525845, 185990469, 189622871, 198989884, 210274845, 210280477, 223382041, 223705042, 224332520, 227639025, 242591280, 244011878, 249565587, 249803978, 252110125, 252215585, 252442769, 252451689
|
||||
| Target and Pathway | |||||
| Target(s) | Proto-oncogene c-Met (MET) | Target Info | Modulator | [4] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| Axon guidance | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Bacterial invasion of epithelial cells | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| Malaria | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Renal cell carcinoma | |||||
| Melanoma | |||||
| Central carbon metabolism in cancer | |||||
| Pathway Interaction Database | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Arf6 signaling events | |||||
| Signaling events mediated by TCPTP | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| Direct p53 effectors | |||||
| Syndecan-1-mediated signaling events | |||||
| Stabilization and expansion of the E-cadherin adherens junction | |||||
| a6b1 and a6b4 Integrin signaling | |||||
| FGF signaling pathway | |||||
| Regulation of retinoblastoma protein | |||||
| Reactome | Sema4D mediated inhibition of cell attachment and migration | ||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Signaling of Hepatocyte Growth Factor Receptor | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Signaling Pathways in Glioblastoma | |||||
| miR-targeted genes in squamous cell - TarBase | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031741) | ||||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | ||||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | ||||
| REF 4 | National Cancer Institute Drug Dictionary (drug id 666907). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.