Drug General Information
Drug ID
D08FDX
Former ID
DNCL002525
Drug Name
MGCD265
Synonyms
MGCD-265; 875337-44-3; MGCD265; MGCD-265 analog; MGCD 265; N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide; UNII-93M6577H9D; CHEMBL254760; 93M6577H9D; n-(3-fluoro-4-(2-(1-methyl-1h-imidazol-4-yl)thieno(3,2-b)pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide; N-[(3-Fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)carbamothioyl]-2-phenylacetamide
Drug Type
Small molecular drug
Indication Non-small-cell lung cancer [ICD-11: 2C25.Y] Phase 2 [1]
Solid tumour/cancer [ICD-11: 2A00-2F9Z] Phase 1 [2]
Company
MethylGene
Structure
Download
2D MOL

3D MOL

Formula
C26H20FN5O2S2
Canonical SMILES
CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(<br />=O)CC5=CC=CC=C5)F
InChI
1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35)
InChIKey
UFICVEHDQUKCEA-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Protein kinase (PK) Target Info Inhibitor [2]
Tyrosine-protein kinase UFO (AXL) Target Info Modulator [3]
NetPath Pathway FSH Signaling Pathway
Pathway Interaction Database Validated transcriptional targets of deltaNp63 isoforms
Reactome VEGFA-VEGFR2 Pathway
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
REF 1 ClinicalTrials.gov (NCT02544633) Phase 2 Study of MGCD265 in Patients With Non-Small Cell Lung Cancer With Activating Genetic Alterations in MET.
REF 2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
REF 3 Company report (Mirati Therapeutics: formerly MethylGene)

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