Drug General Information
Drug ID
D0B9OG
Former ID
DIB005977
Drug Name
Adipiplon
Synonyms
GABA modulator (insomnia), Neurogen; NG-2-73
Drug Type
Small molecular drug
Indication Sleep-wake disorder [ICD-11: 7A00-7B2Z; ICD-10: G47] Phase 2 [1]
Company
Neurogen Corporation
Structure
Download
2D MOL

3D MOL

Formula
C18H18FN7
Canonical SMILES
c1n2c(c(c(n1)Cn1c(ncc1)c1c(cccn1)F)CCC)nc(n2)C
CAS Number
CAS 840486-93-3
PubChem Compound ID
Target and Pathway
Target(s) GABA(A) receptor alpha-3 (GABRA3) Target Info Modulator [2]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
REF 1 ClinicalTrials.gov (NCT00683436) Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs. U.S. National Institutes of Health.
REF 2 Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.

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