Drug General Information
Drug ID
D0G3TJ
Former ID
DIB016074
Drug Name
ASKP-1240
Synonyms
Anti-CD40 mAb (organ transplant rejection/autoimmune disease), Kirin/Astellas; Anti-CD40 mAb (organ transplant rejection/autoimmune disease), Kyowa Hakko Kirin/Astellas; 4D11
Drug Type
Antibody
Indication Transplant rejection [ICD-11: NE84; ICD-9: 279.5, 996] Phase 2 [1]
Company
Astellas pharma us; kyowa hakko kirin pharma
Target and Pathway
Target(s) CD40L receptor (CD40) Target Info . [2]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Malaria
Toxoplasmosis
HTLV-I infection
Epstein-Barr virus infection
Transcriptional misregulation in cancer
Asthma
Autoimmune thyroid disease
Systemic lupus erythematosus
Allograft rejection
Primary immunodeficiency
Viral myocarditis
Pathway Interaction Database CD40/CD40L signaling
WikiPathways Toll-like receptor signaling pathway
Inflammatory Response Pathway
NLR Proteins
Vitamin D Receptor Pathway
Human Complement System
Allograft Rejection
Regulation of toll-like receptor signaling pathway
References
REF 1 ClinicalTrials.gov (NCT01585233) A Multiple Dose Escalation Study of ASKP1240 in Subjects With Moderate to Severe Plaque Psoriasis. U.S. National Institutes of Health.
REF 2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).

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