Drug General Information
Drug ID
D0KG3R
Former ID
DNAP001688
Drug Name
Rivaroxaban
Synonyms
XARELTO (TN)
Drug Type
Small molecular drug
Indication Deep vein thrombosis [ICD-11: BD71; ICD-10: I80-I82, I80.2] Approved [1], [2]
Company
Bayer HealthCare Pharmaceuticals; Johnson & Johnson Pharmaceutical Research & Development
Structure
Download
2D MOL

3D MOL

Formula
C19H18ClN3O5S
InChI
1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChIKey
KGFYHTZWPPHNLQ-AWEZNQCLSA-N
CAS Number
CAS 366789-02-8
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:68579
SuperDrug ATC ID
B01AF01
Target and Pathway
Target(s) Coagulation factor Xa (F10) Target Info Modulator [3]
KEGG Pathway Complement and coagulation cascades
Panther Pathway Blood coagulation
Pathwhiz Pathway Coagulation
Pathway Interaction Database Beta2 integrin cell surface interactions
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
Human Complement System
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6388).
REF 2 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
REF 3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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