Drug General Information
Drug ID
D0M6DO
Former ID
DAP000842
Drug Name
Aminoglutethimide
Synonyms
Aminoglutethimidum; Aminoglutetimida; Cytadren; Elipten; Orimeten; Ciba Vision Brand of Aminoglutethimide; Novartis Brand of Aminoglutethimide; A 9657; Ba 16038; AG-1; Aminoglutethimide (AG); Aminoglutethimide [INN:BAN]; Aminoglutethimidum [INN-Latin]; Aminoglutetimida [INN-Spanish]; Ba-16038; C 16038-BA; Cytadren (TN); Dl-Aminoglutethimide; P-Aminoglutethimide; Aminoglutethimide (USP/INN); Glutethimide, para-amino; Alpha-(p-Aminophenyl)-alpha-ethylglutarimide; (+-)-3-(p-Aminophenyl)-3-ethyl-2,6-piperidinedione; (+/-)-p-AMINOGLUTETHIMIDE; (inverted question mark)-p-Aminoglutethimide; 2-(p-Aminophenyl)-2-ethylglutarimide; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidindion; 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione; 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione; 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione; 3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine
Drug Type
Small molecular drug
Indication Cushing disease [ICD-11: 5A70] Approved [1], [2]
Therapeutic Class
Anticancer Agents
Company
Norvatis Phamaceuticals Corporation
Structure
Download
2D MOL

3D MOL

Formula
C13H16N2O2
InChI
1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
InChIKey
ROBVIMPUHSLWNV-UHFFFAOYSA-N
CAS Number
CAS 125-84-8
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
L02BG01
SuperDrug CAS ID
cas=000125848
Target and Pathway
Target(s) Aromatase (CYP19A1) Target Info Inhibitor [3]
Cholesterol desmolase (CYP11A1) Target Info Inhibitor [2]
BioCyc Superpathway of steroid hormone biosynthesis
Pregnenolone biosynthesis
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
Panther Pathway Androgen/estrogene/progesterone biosynthesis
Pathwhiz Pathway Steroidogenesis
Reactome Endogenous sterols
WikiPathways Prostaglandin Synthesis and Regulation
Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
Corticotropin-releasing hormone
Phase 1 - Functionalization of compounds
Phase 1 - Functionalization of compounds
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7054).
REF 2 Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15.
REF 3 Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45.

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