Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0U3KP
|
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| Former ID |
DIB013178
|
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| Drug Name |
HT-100
|
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| Synonyms |
Halofunginone
|
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| Drug Type |
Small molecular drug
|
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| Indication | Duchenne dystrophy [ICD-11: 8C70; ICD-10: G71.0] | Phase 2 | [1] | ||
| Company |
Halo therapeutics
|
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| Structure |
 |
Download2D MOL |
|||
| Formula |
C16H18Br2ClN3O3
|
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| Canonical SMILES |
C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
|
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| InChI |
1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H
|
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| InChIKey |
SJUWEPZBTXEUMU-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Bifunctional aminoacyl-tRNA synthetase (EPRS) | Target Info | Modulator | [2] | |
| BioCyc | TRNA charging | ||||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | ||||
| Aminoacyl-tRNA biosynthesis | |||||
| Metabolic pathways | |||||
| Panther Pathway | Heme biosynthesis | ||||
| Pathwhiz Pathway | Arginine and Proline Metabolism | ||||
| WikiPathways | Parkinsons Disease Pathway | ||||
| tRNA Aminoacylation | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02525302) HT-100 Long-term Study in DMD Patients Who Completed HALO-DMD-02. | ||||
| REF 2 | Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. | ||||
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