Drug General Information
Drug ID
D00SBN
Former ID
DAP000957
Drug Name
Perhexiline
Synonyms
Perhexilene; Perhexilina; Perhexilinum; Perhexilline; Perhexilina [INN-Spanish]; Perhexiline (INN); Perhexiline [INN:BAN]; Perhexilinum [INN-Latin]; (+)-2-(2,2-Dicyclohexylethyl)piperidine; (-)-2-(2,2-Dicyclohexylethyl)piperidine; 2-(2,2-Dicyclohexylethyl)piperidine
Drug Type
Small molecular drug
Indication Angina pectoris [ICD-11: BA40; ICD-9: 413] Approved [1]
Therapeutic Class
Vasodilator Agents
Structure
Download
2D MOL

3D MOL

Formula
C19H35N
Canonical SMILES
C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChI
1S/C19H35N/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18/h16-20H,1-15H2
InChIKey
CYXKNKQEMFBLER-UHFFFAOYSA-N
CAS Number
CAS 6621-47-2
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:35553
SuperDrug ATC ID
C08EX02
SuperDrug CAS ID
cas=006621472
Target and Pathway
Target(s) Carnitine O-palmitoyltransferase I (CPT1B) Target Info Inhibitor [1]
KEGG Pathway Fatty acid degradation
Fatty acid metabolism
PPAR signaling pathway
AMPK signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Pathwhiz Pathway Fatty acid Metabolism
Reactome RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
REF 1 Perhexiline. Cardiovasc Drug Rev. 2007 Spring;25(1):76-97.

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