Drug Information
Drug General Information | Top | |||
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Drug ID |
D03PTH
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Former ID |
DIB016508
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Drug Name |
Pyrantel
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Synonyms |
PYRANTEL; Pyrequan; 15686-83-6; Strongid; Pirantele [DCIT]; Pyrantelum; Pirantel; Pyrantel [INN:BAN]; Pyrantelum [INN-Latin]; Pirantel [INN-Spanish]; UNII-4QIH0N49E7; HSDB 3252; EINECS 239-774-1; CHEBI:8654; 4QIH0N49E7; (E)-1-Methyl-2-(2-(thiophen-2-yl)vinyl)-1,4,5,6-tetrahydropyrimidine; E-1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine; Pirantele; 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine; Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-, (E)-; Pin-X
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Drug Type |
Small molecular drug
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Indication | Worm infection [ICD-11: 1F90.Z; ICD-9: 120-129] | Approved | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H14N2S
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Canonical SMILES |
CN1CCCN=C1C=CC2=CC=CS2
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InChI |
1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
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InChIKey |
YSAUAVHXTIETRK-AATRIKPKSA-N
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CAS Number |
CAS 15686-83-6
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:8654
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ADReCS Drug ID | BADD_D01878 |
Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroidaceae
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[2] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Bacteroidaceae was increased by Pyrantel pamoate. | |||
Studied Microbe: Bacteroides
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[2] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Bacteroides was increased by Pyrantel pamoate. | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
Studied Microbe: Enterobacteriaceae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Enterobacteriaceae was decreased by Pyrantel pamoate. | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
Studied Microbe: Lactobacillaceae
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[2] | |||
Hierarchy | ||||
Abundance Change | Increase | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Lactobacillaceae was increased by Pyrantel pamoate. | |||
Studied Microbe: Lactococcus
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Lactococcus was decreased by Pyrantel pamoate. | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
Studied Microbe: Akkermansia
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Akkermansia was decreased by Pyrantel pamoate. | |||
Studied Microbe: Akkermansia muciniphila
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Akkermansia muciniphila was decreased by Pyrantel pamoate. | |||
Studied Microbe: Verrucomicrobiaceae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Verrucomicrobiaceae was decreased by Pyrantel pamoate. | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
Studied Microbe: Verrucomicrobiae
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Verrucomicrobiae was decreased by Pyrantel pamoate. | |||
Studied Microbe: Verrucomicrobiales
Show/Hide Hierarchy
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experimental Species | Human | Experimental Sample | Faeces | |
Disease or Condition | Gastrointestinal helminths infection | |||
Description | The abundance of Verrucomicrobiales was decreased by Pyrantel pamoate. |
References | Top | |||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | Infections by human gastrointestinal helminths are associated with changes in faecal microbiota diversity and composition. PLoS One. 2017 Sep 11;12(9):e0184719. |
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