Drug Information
Drug General Information | Top | |||
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Drug ID |
D03RNX
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Former ID |
DIB001692
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Drug Name |
EPC-K1
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Synonyms |
CHX-3107; Phosphoric acid 2-L-ascorbyl D,L-alpha-tocopheryl diester potassium salt; 2-O-[Hydroxy[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yloxy]phosphoryl]-L-ascorbic acid potassium salt
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Drug Type |
Small molecular drug
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Indication | Nerve injury [ICD-11: ND56.4; ICD-10: T14.4] | Discontinued in Phase 2 | [1] | |
Structure |
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Download2D MOL
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Formula |
C35H56KO10P
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Canonical SMILES |
CC1=C(C(=C(C2=C1OC(CC2)(C)CCCC(C)CCCC(C)CCCC(C)C)C)OP(=O)([O-])OC3=C(C(OC3=O)C(CO)O)O)C.[K+]
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InChI |
1S/C35H57O10P.K/c1-21(2)12-9-13-22(3)14-10-15-23(4)16-11-18-35(8)19-17-27-26(7)30(24(5)25(6)31(27)43-35)44-46(40,41)45-33-29(38)32(28(37)20-36)42-34(33)39;/h21-23,28,32,36-38H,9-20H2,1-8H3,(H,40,41);/q;+1/p-1/t22-,23-,28+,32-,35-;/m1./s1
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InChIKey |
VIHIKSJKXIMMLV-FZTHFCCHSA-M
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CAS Number |
CAS 127061-56-7
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Phospholipase A2 (PLA2G1B) | Target Info | Inhibitor | [2], [3] |
BioCyc | Phospholipases | |||
KEGG Pathway | Glycerophospholipid metabolism | |||
Ether lipid metabolism | ||||
Arachidonic acid metabolism | ||||
Linoleic acid metabolism | ||||
alpha-Linolenic acid metabolism | ||||
Metabolic pathways | ||||
Ras signaling pathway | ||||
Vascular smooth muscle contraction | ||||
Pancreatic secretion | ||||
Fat digestion and absorption | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
Reactome | Acyl chain remodelling of PC | |||
Acyl chain remodelling of PE | ||||
Acyl chain remodelling of PI | ||||
WikiPathways | Glycerophospholipid biosynthesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007770) | |||
REF 2 | Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats. Brain Res Bull. 1995;36(3):257-60. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 |
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