Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06EWO
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| Former ID |
DAP000390
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| Drug Name |
Gemtuzumab ozogamicin
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| Synonyms |
Mylotarg (TN)
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| Drug Type |
Antibody
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Approved | [1], [2] | |
| Therapeutic Class |
Anticancer Agents
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| Company |
Wyeth Pharmaceuticals
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| ADReCS Drug ID | BADD_D01015 | |||
| SuperDrug ATC ID |
L01XC05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Myeloid cell surface antigen CD33 (CD33) | Target Info | . | [3], [4], [5], [6], [7] |
| KEGG Pathway | Hematopoietic cell lineage | |||
| Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6775). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin. Clin Interv Aging. 2009;4:197-205. | |||
| REF 4 | Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML. Exp Hematol. 2009 Jun;37(6):755-66. | |||
| REF 5 | Successful treatment with gemtuzumab ozogamicin monotherapy in a pediatric patient with resistant relapse of acute myeloid leukemia. Turk J Pediatr. 2009 Jan-Feb;51(1):69-71. | |||
| REF 6 | Phase I/II study of humanized anti-CD33 antibody conjugated with calicheamicin, gemtuzumab ozogamicin, in relapsed or refractory acute myeloid leuk... Int J Hematol. 2009 May;89(4):460-469. | |||
| REF 7 | Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. | |||
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