Drug General Information
Drug ID
D07EEN
Former ID
DCL000870
Drug Name
Lixivaptan
Synonyms
168079-32-1; VPA-985; WAY-VPA-985; UNII-8F5X4B082E; VPA985; CHEMBL49429; CRTX-080; VPA 985; 8F5X4B082E; N-[3-chloro-4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]-5-fluoro-2-methylbenzamide; Lixar; Lixivaptan [USAN:INN]; Lixivaptan (USAN/INN); WAY VPA-985; Lixivaptan (VPA-985); AC1L59LM; WAY-VPA 985; GTPL2238; SCHEMBL1649340; DTXSID00168472; PPHTXRNHTVLQED-UHFFFAOYSA-N; ZINC600399; EX-A1129; BCP09167; BDBM50065115; AKOS022181388; AN-1842; CS-7512; API0009250; NCGC00485402-01; VPA985; BF-Derm1
Drug Type
Small molecular drug
Indication Hyponatraemia [ICD-11: 5C72; ICD-10: E87; ICD-9: 276.1] Phase 3 [1], [2]
Congestive heart failure [ICD-11: BD10; ICD-10: I50.0; ICD-9: 428] Phase 2 [1], [2]
Skin infection [ICD-11: 1F28-1G0Z; ICD-10: L00-L99; ICD-9: 680-709] Phase 2 [3]
Company
Wyeth-Ayerst; Cardiokine
Structure
Download
2D MOL

3D MOL

Formula
C27H21ClFN3O2
InChI
1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
InChIKey
PPHTXRNHTVLQED-UHFFFAOYSA-N
CAS Number
CAS 168079-32-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histidine decarboxylase (HDC) Target Info Inhibitor [4]
Vasopressin V2 receptor (V2R) Target Info Antagonist [5]
KEGG Pathway Histidine metabolism
Metabolic pathways
Panther Pathway Histamine synthesis
CCKR signaling map ST
Pathwhiz Pathway Histidine Metabolism
Pathway Interaction Database Arf6 trafficking events
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2238).
REF 2 Physical state of kappa-carrageenan modulates the mode of action of kappa-carrageenase from Pseudoalteromonas carrageenovora. Biochem J. 2009 May 1;419(3):545-53.
REF 3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020550)
REF 4 Clinical pipeline report, company report or official report of Biofrontera (2009).
REF 5 Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95.

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