Drug Information
Drug General Information | Top | |||
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Drug ID |
D08JVS
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Former ID |
DIB010604
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Drug Name |
NU-206
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Synonyms |
HRSpo-1; Secreted proteins (IBD), ARCA; Secreted proteins (mucositis), ARCA; Secreted proteins (GI and bone diseases),Kyowa Hakko Kirin/ARCA; Secreted proteins (IBD), Kirin/ARCA; Secreted proteins (inflammatory bowel disease), ARCA/Kirin; Secreted proteins (mucositis), Kirin/ARCA; Human R-Spondin-1 (GI and bone diseases), ARCA; Low-density lipoprotein receptor related protein 6 (IBD), Kirin/ARCA
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Indication | Gastrointestinal disease [ICD-11: DE2Z] | Phase 1 | [1], [2] | |
Company |
Kirin Brewery Co Ltd
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Target and Pathway | Top | |||
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Target(s) | Roof plate-specific spondin-1 (RSPO1) | Target Info | Modulator | [3] |
Pathway Interaction Database | Wnt signaling network | |||
Reactome | Regulation of FZD by ubiquitination |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3697). | |||
REF 2 | R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. | |||
REF 3 | R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.BMC Dev Biol.2008 Apr 2;8:36. |
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