Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08WSY
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| Former ID |
DCL000516
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| Drug Name |
Denosumab
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| Synonyms |
Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
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| Drug Type |
Antibody
|
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| Indication | Postmenopausal osteoporosis [ICD-11: FB83.11; ICD-10: M81.0; ICD-9: 733] | Approved | [1], [2] | |
| Prostate cancer [ICD-11: 2C82.0; ICD-10: C61, C79.51; ICD-9: 185, 198.5] | Phase 3 | [1], [2] | ||
| Rheumatoid arthritis [ICD-11: FA20] | Phase 2 | [1], [2] | ||
| Company |
Amgen
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| PubChem Substance ID | ||||
| ADReCS Drug ID | BADD_D00608 | |||
| SuperDrug ATC ID |
M05BX04
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Osteoclast differentiation factor (ODF) | Target Info | . | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| NF-kappa B signaling pathway | ||||
| Osteoclast differentiation | ||||
| Prolactin signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | Leptin Signaling Pathway | |||
| TWEAK Signaling Pathway | ||||
| Pathway Interaction Database | IL6-mediated signaling events | |||
| Reactome | TNFR2 non-canonical NF-kB pathway | |||
| TNFs bind their physiological receptors | ||||
| TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
| WikiPathways | Osteoblast Signaling | |||
| Vitamin D Receptor Pathway | ||||
| Differentiation Pathway | ||||
| RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886). | |||
| REF 2 | Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. | |||
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