Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09KLR
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| Former ID |
DAP000182
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| Drug Name |
Alendronate
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| Synonyms |
Arendal; Fosamax; ALENDRONATE SODIUM; ALENDRONIC ACID; Acide alendronique; Acido alendronico; Acidum alendronicum; MK 217; Acide alendronique [INN-French]; Acido alendronico [INN-Spanish]; Acidum alendronicum [INN-Latin]; Alendronic acid (INN); Alendronic acid [INN:BAN]; Bisphosphonate, 65; Fosamax (TN); MK-217; Phosphonic acid, (4-amino-1-hydroxybutylidene)bis; (4-Amino-1-hydroxybutylidene)bisphosphonic acid; (4-Amino-1-hydroxybutylidene)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid; (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid); 4-Amino-1-hydroxybutane-1,1-diphosphonate; 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid; 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid); 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
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| Drug Type |
Small molecular drug
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| Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Approved | [1], [2] | |
| Paget's disease [ICD-11: FB85] | Approved | [1], [2] | ||
| Therapeutic Class |
Bone Density Conservation Agents
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| Company |
Teva Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C4H13NO7P2
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| Canonical SMILES |
C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
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| InChI |
1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
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| InChIKey |
OGSPWJRAVKPPFI-UHFFFAOYSA-N
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| CAS Number |
CAS 66376-36-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9954, 649130, 7344414, 7978659, 8151420, 10318378, 15196679, 26612802, 26750071, 29215185, 29215186, 29221268, 46393653, 46507199, 47291221, 48110541, 48415528, 50007414, 50659878, 51091458, 53790851, 53801179, 56374454, 57321131, 87560297, 93166338, 103228757, 104299568, 105562999, 118402569, 125645927, 126524218, 126685342, 127330008, 127330009, 127330010, 127330011, 127330012, 127330186, 127330187, 127330188, 127330189, 128806596, 131322978, 131349593, 134337502, 135007310, 135366402, 135649795, 136991069
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| ChEBI ID |
CHEBI:2567
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| ADReCS Drug ID | BADD_D00065 ; BADD_D00066 | |||
| SuperDrug ATC ID |
M05BA04
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| SuperDrug CAS ID |
cas=066376361
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Geranyltranstransferase (FDPS) | Target Info | Modulator | [3] |
| BioCyc | Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) | |||
| Superpathway of cholesterol biosynthesis | ||||
| Trans, trans-farnesyl diphosphate biosynthesis | ||||
| Geranylgeranyldiphosphate biosynthesis | ||||
| KEGG Pathway | Terpenoid backbone biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Influenza A | ||||
| HTLV-I infection | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | |||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3141). | |||
| REF 2 | Osteonecrosis of the jaw. South Med J. 2008 Feb;101(2):160-5. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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