Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B1IV
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| Former ID |
DIB015128
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| Drug Name |
Vancomycin
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| Synonyms |
Vancomycin (oral, MRSA), AuricX; Vancomycin (oral/pill, MSRA); Vancomycin (oral/pill, MSRA), AuricX/SRI International
Click to Show/Hide
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| Indication | Methicillin-resistant staphylococci infection [ICD-11: 1A00-1A09; ICD-10: A00-B99] | Approved | [1] | |
| MRSA infection [ICD-11: 1D01.0Y; ICD-10: A49.02; ICD-9: 41.12] | Investigative | [2] | ||
| Therapeutic Class |
Antiinfective Agents
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| Company |
AuricX Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL
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| Formula |
C66H75Cl2N9O24
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| Canonical SMILES |
CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O
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| InChI |
1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1
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| InChIKey |
MYPYJXKWCTUITO-LYRMYLQWSA-N
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| CAS Number |
CAS 1404-90-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:28001
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| ADReCS Drug ID | BADD_D02332 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Staphylococcus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Staphylococcus was decreased by Vancomycin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Alistipes
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Alistipes was decreased by Vancomycin. | |||
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Studied Microbe: Bacteroides
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was decreased by Vancomycin. | |||
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Studied Microbe: Bacteroides
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was decreased by Vancomycin (p < 0.05). | |||
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Studied Microbe: Bacteroides caccae
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Vancomycin hydrochloride (adjusted p-values: 4.51E-05). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Vancomycin hydrochloride (adjusted p-values: 5.86E-06). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Vancomycin hydrochloride (adjusted p-values: 3.90E-03). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Vancomycin hydrochloride (adjusted p-values: 1.60E-03). | |||
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Studied Microbe: Bacteroides uniformis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Vancomycin hydrochloride (adjusted p-values: 4.87E-03). | |||
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Studied Microbe: Bacteroides vulgatus
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Vancomycin hydrochloride (adjusted p-values: 2.05E-06). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Vancomycin hydrochloride (adjusted p-values: 9.24E-03). | |||
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Studied Microbe: Barnesiella
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Barnesiella was decreased by Vancomycin. | |||
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Studied Microbe: Parabacteroides merdae
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Vancomycin hydrochloride (adjusted p-values: 1.81E-04). | |||
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Studied Microbe: Porphyromonadaceae
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Porphyromonadaceae was decreased by Vancomycin. | |||
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Studied Microbe: Prevotella copri
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Vancomycin hydrochloride (adjusted p-values: 2.80E-03). | |||
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Studied Microbe: Prevotellaceae
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Non-obese diabetic mice | Experimental Sample | Faeces | |
| Disease or Condition | Autoimmune insulin-dependent diabetes | |||
| Description | The abundance of Prevotellaceae was decreased by Vancomycin. | |||
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Studied Microbe: Rikenellaceae
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Non-obese diabetic mice | Experimental Sample | Faeces | |
| Disease or Condition | Autoimmune insulin-dependent diabetes | |||
| Description | The abundance of Rikenellaceae was decreased by Vancomycin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bifidobacterium was decreased by Vancomycin (p < 0.05). | |||
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Studied Microbe: Bifidobacterium adolescentis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Vancomycin hydrochloride (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Vancomycin hydrochloride (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Vancomycin hydrochloride (adjusted p-values: 4.93E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Vancomycin hydrochloride (adjusted p-values: 1.02E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Enterobacteriaceae
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Enterobacteriaceae was increased by Vancomycin. | |||
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Studied Microbe: Escherichia
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Escherichia was increased by Vancomycin. | |||
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Studied Microbe: Klebsiella
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Klebsiella was increased by Vancomycin (p < 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Vancomycin hydrochloride (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Vancomycin hydrochloride (adjusted p-values: 7.48E-07). | |||
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Studied Microbe: Clostridiaceae
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Clostridiaceae was increased by Vancomycin. | |||
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Studied Microbe: Clostridioides difficile
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Vancomycin hydrochloride (adjusted p-values: 5.05E-06). | |||
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Studied Microbe: Clostridium perfringens
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Vancomycin hydrochloride (adjusted p-values: 2.36E-06). | |||
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Studied Microbe: Coprococcus comes
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Vancomycin hydrochloride (adjusted p-values: 3.12E-05). | |||
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Studied Microbe: Dorea formicigenerans
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Vancomycin hydrochloride (adjusted p-values: 5.09E-06). | |||
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Studied Microbe: Enterocloster bolteae
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Vancomycin hydrochloride (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Eubacterium eligens
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Vancomycin hydrochloride (adjusted p-values: 5.86E-06). | |||
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Studied Microbe: Eubacterium rectale
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Vancomycin hydrochloride (adjusted p-values: 4.03E-04). | |||
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Studied Microbe: Lachnospiraceae
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Non-obese diabetic mice | Experimental Sample | Faeces | |
| Disease or Condition | Autoimmune insulin-dependent diabetes | |||
| Description | The abundance of Lachnospiraceae was decreased by Vancomycin. | |||
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Studied Microbe: Lacrimispora saccharolytica
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Vancomycin hydrochloride (adjusted p-values: 2.74E-07). | |||
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Studied Microbe: Roseburia hominis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Vancomycin hydrochloride (adjusted p-values: 1.70E-05). | |||
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Studied Microbe: Roseburia intestinalis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Vancomycin hydrochloride (adjusted p-values: 3.62E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Vancomycin hydrochloride (adjusted p-values: 6.14E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Vancomycin hydrochloride (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Ruminococcus torques
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Vancomycin hydrochloride (adjusted p-values: 6.45E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus durans
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus durans was decreased by Vancomycin (p < 0.05). | |||
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Studied Microbe: Enterococcus faecalis
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus faecalis was decreased by Vancomycin (p < 0.05). | |||
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Studied Microbe: Enterococcus faecium
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus faecium was decreased by Vancomycin (p < 0.05). | |||
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Studied Microbe: Lactobacillus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was increased by Vancomycin. | |||
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Studied Microbe: Pediococcus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Pediococcus was increased by Vancomycin (p < 0.01). | |||
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Studied Microbe: Streptococcus parasanguinis
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Vancomycin hydrochloride (adjusted p-values: 6.92E-07). | |||
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Studied Microbe: Streptococcus salivarius
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[6] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Vancomycin hydrochloride (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Verrucomicrobiales | ||||
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Studied Microbe: Akkermansia
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Akkermansia was increased by Vancomycin. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
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Studied Microbe: Bacteroidales
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Bacteroidales was decreased by Vancomycin (p < 0.01). | |||
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Studied Microbe: Clostridiales
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[7] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Non-obese diabetic mice | Experimental Sample | Faeces | |
| Disease or Condition | Autoimmune insulin-dependent diabetes | |||
| Description | The abundance of Clostridiales was decreased by Vancomycin. | |||
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Studied Microbe: Enterobacterales
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Enterobacterales was increased by Vancomycin (p < 0.01). | |||
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Studied Microbe: Eubacteriales
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Eubacteriales was increased by Vancomycin (p < 0.01). | |||
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Studied Microbe: Firmicutes
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Obesity | |||
| Description | The abundance of Firmicutes was decreased by Vancomycin. | |||
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Studied Microbe: Proteobacteria
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[8] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | Clostridium difficile infection | |||
| Description | The abundance of Proteobacteria was decreased by Vancomycin. | |||
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Studied Microbe: Proteobacteria
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[9] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Obesity | |||
| Description | The abundance of Proteobacteria was increased by Vancomycin. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
| REF 3 | Influence of oral glycopeptides on the fecal flora of human volunteers: selection of highly glycopeptide-resistant enterococci. J Infect Dis. 1996 May;173(5):1129-36. | |||
| REF 4 | Antibiotic-Induced Alterations of the Murine Gut Microbiota and Subsequent Effects on Colonization Resistance against Clostridium difficile. mBio. 2015 Jul 14;6(4):e00974. | |||
| REF 5 | Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy. Clin Infect Dis. 1997 Sep;25(3):729-32. | |||
| REF 6 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 7 | Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PLoS One. 2015 May 13;10(5):e0125448. | |||
| REF 8 | Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment. Antimicrob Agents Chemother. 2015 Jul;59(7):3726-35. | |||
| REF 9 | Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. J Hepatol. 2014 Apr;60(4):824-31. | |||
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