Drug General Information
Drug ID
D0F2JS
Former ID
DCL000085
Drug Name
CHR-2797
Synonyms
Tosedostat; Tosedostat, CHR2797, CHR-2797
Drug Type
Small molecular drug
Indication Acute myeloid leukaemia [ICD-11: 2A60] Phase 2 [1], [2]
Myelodysplastic syndrome [ICD-11: 2A37; ICD-9: 238.7] Phase 2 [2]
Therapeutic Class
Anticancer Agents
Company
Chroma Therape.
Structure
Download
2D MOL

3D MOL

Formula
C21H30N2O6
Canonical SMILES
CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
InChI
1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
InChIKey
FWFGIHPGRQZWIW-SQNIBIBYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Aminopeptidase (AMP) Target Info Inhibitor [2]
Puromycin-sensitive aminopeptidase (NPEPPS) Target Info Inhibitor [3]
Reactome Antigen processing: Ubiquitination & Proteasome degradation
References
REF 1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022187)
REF 2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
REF 3 CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Wang and Dr. Li.