Drug General Information
Drug ID
D0H5HZ
Former ID
DIB007148
Drug Name
Etamicastat
Synonyms
BIA-5453; Dopamine beta hydroxylase inhibitors (cardiovascular diseases), BIAL; Dopamine beta hydroxylase inhibitors (cardiovascular diseases), Portela
Drug Type
Small molecular drug
Indication Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] Phase 2 [1]
Company
Portela & Ca SA
Structure
Download
2D MOL

3D MOL

Formula
C14H15F2N3OS
Canonical SMILES
c1(c[nH]c(=S)n1[C@@H]1Cc2cc(cc(c2OC1)F)F)CCN
PubChem Compound ID
Target and Pathway
Target(s) Dopamine beta hydroxylase (DBH) Target Info Inhibitor [2]
BioCyc Catecholamine biosynthesis
KEGG Pathway Tyrosine metabolism
Metabolic pathways
Panther Pathway Adrenaline and noradrenaline biosynthesis
Dopamine receptor mediated signaling pathway
Pathwhiz Pathway Catecholamine Biosynthesis
Tyrosine Metabolism
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Metabolism of amino acids and derivatives
References
REF 1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034724)
REF 2 Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-beta-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects. Drugs R D. 2010;10(4):225-42.

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