Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H8VY
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Former ID |
DCL000072
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Drug Name |
BMS-201038
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Synonyms |
AEGR 733; AEGR733; BMS 201038; BMS 201238; BMS201038; AEGR-733; BMS 201038-01
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Drug Type |
Small molecular drug
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Indication | Familial hypercholesterolemia [ICD-11: 5C80.00; ICD-10: E78.0; ICD-9: 272] | Approved | [1], [2] | |
Company |
Bristol-Myers Squibb
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Structure |
Download2D MOL |
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Formula |
C39H37F6N3O2
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Canonical SMILES |
C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
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InChI |
1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
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InChIKey |
MBBCVAKAJPKAKM-UHFFFAOYSA-N
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CAS Number |
CAS 182431-12-5
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PubChem Compound ID | ||||
PubChem Substance ID |
14815135, 24148206, 45275369, 77003727, 103426685, 103995395, 124490377, 126681450, 128569932, 135194833, 137125822, 142063799, 160962914, 162224728, 172918127, 175266823, 175427108, 178104011, 189294433, 198991931, 223218466, 223662329, 226644605, 251970555, 252450349, 252558102, 252672097, 252822638
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ChEBI ID |
CHEBI:72297
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ADReCS Drug ID | BADD_D01311 ; BADD_D01312 |
Target and Pathway | Top | |||
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Target(s) | Microsomal triglyceride transfer protein (MTTP) | Target Info | Inhibitor | [3], [4] |
KEGG Pathway | Fat digestion and absorption | |||
Reactome | Chylomicron-mediated lipid transport | |||
WikiPathways | Statin Pathway | |||
Lipid digestion, mobilization, and transport |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7439). | |||
REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | |||
REF 3 | Dyslipidemia and cardiovascular diseases. Curr Opin Lipidol. 2009 Apr;20(2):157-8. | |||
REF 4 | Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):231-45. |
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