Drug General Information
Drug ID
D0LJ8C
Former ID
DNCL001875
Drug Name
LCZ696
Synonyms
DTXSID50239500
Drug Type
Small molecular drug
Indication Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] Approved [1]
Company
Novartis Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C48H64N6Na3O11+3
Canonical SMILES
CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C<br />(=O)O.CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CC<br />C(=O)O.O.O.O.[Na+].[Na+].[Na+]
InChI
1S/C24H29N5O3.C24H29NO5.3Na.3H2O/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23;1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;;;;;;/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28);4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);;;;3*1H2/q;;3*+1;;;/t22-;17-,21+;;;;;;/m01....../s1
InChIKey
ACXLNSLRLQLEAL-HWSDWTSLSA-N
PubChem Compound ID
Target and Pathway
Target(s) Neutral endopeptidase (MME) Target Info Modulator [1]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
REF 1 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.

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