Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W8SB
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| Former ID |
DAP000938
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| Drug Name |
Penbutolol
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| Synonyms |
Betapressin; Levatol; Levatolol; Levopenbutol; Lobeta; Paginol; Penbutololum; PENBUTOLOL SULFATE; HOE 893; HOE 893d; Betapressin (TN); Hostabloc (TN); L-Penbutolol; Levatol (TN); Levatolol (TN); Lobeta (TN); Paginol (TN); Penbutolol (INN); Penbutolol [INN:BAN]; Penbutololum [INN-Latin]; Penbutolol Sulfate (2:1); S(-)-Penbutolol; (-)-Penbutolol; (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol; 1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)propan-2-ol
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H29NO2
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| Canonical SMILES |
CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O
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| InChI |
1S/C18H29NO2/c1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14/h6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3/t15-/m0/s1
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| InChIKey |
KQXKVJAGOJTNJS-HNNXBMFYSA-N
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| CAS Number |
CAS 38363-40-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9620, 8175027, 15902888, 34678763, 46504929, 47291267, 47589134, 48416387, 50022970, 50064728, 57312048, 77621769, 96024764, 103293389, 103400617, 104326642, 117556859, 124954107, 128421871, 134223256, 134338213, 134999314, 135049302, 137001394, 142047536, 160964648, 175266991, 178103837, 179150414, 223440604, 226426442
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| ChEBI ID |
CHEBI:7954
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| ADReCS Drug ID | BADD_D01706 ; BADD_D01707 | |||
| SuperDrug ATC ID |
C07AA23
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| SuperDrug CAS ID |
cas=036507489
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Penbutolol sulfate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.442; p = 0.02). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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|
[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Penbutolol sulfate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.48; p = 0.021). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Eubacterium biforme DSM 3989
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|
[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Penbutolol sulfate can be metabolized by Eubacterium biforme DSM 3989 (log2FC = -0.356; p = 0.025). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Clostridium sp.
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|
[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Penbutolol sulfate can be metabolized by Clostridium sp. (log2FC = -0.44; p = 0.029). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor beta-1 (ADRB1) | Target Info | Antagonist | [5], [6] |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Endocytosis | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Gap junction | ||||
| Salivary secretion | ||||
| Dilated cardiomyopathy | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Beta1 adrenergic receptor signaling pathway | ||||
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Adrenoceptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Endothelin Pathways | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7263). | |||
| REF 2 | Penbutolol and carteolol: two new beta-adrenergic blockers with partial agonism. J Clin Pharmacol. 1990 May;30(5):412-21. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | beta-Adrenergic receptor blockers--a group of chiral drugs: different effects of each enantiomer. Ceska Slov Farm. 2002 May;51(3):121-8. | |||
| REF 6 | Decrease in penbutolol central response as a cause of changes in its serum protein binding. J Pharm Pharmacol. 1990 Mar;42(3):164-6. | |||
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