Drug General Information
Drug ID
D0WY5Q
Former ID
DIB002950
Drug Name
Rivastigmine
Synonyms
Rivastigmine (transdermal patch)
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] Approved [1], [2]
Company
Samyang Corp
Structure
Download
2D MOL

3D MOL

Formula
C14H22N2O2
InChI
1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
InChIKey
XSVMFMHYUFZWBK-NSHDSACASA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Acetylcholinesterase (AChE) Target Info Modulator [3]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
Panther Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathwhiz Pathway Phospholipid Biosynthesis
Pathway Interaction Database ATF-2 transcription factor network
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
REF 1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6602).
REF 2 ClinicalTrials.gov (NCT00948766) Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44. U.S. National Institutes of Health.
REF 3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).

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