Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T05849 | ||||
| Target Name | Gastrin/cholecystokinin type B receptor (CCKBR) | ||||
| Synonyms | Cholecystokinin-2 receptor; CCKRB; CCK2-R; CCK-BR; CCK-B receptor | ||||
| Target Type | Successful | ||||
| Gene Name | CCKBR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | GASR_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Ulcerative colitis | ||||
| Example drug | GASTRAZOLE | Phase 3 | [1], [2], [3] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.12 Z-score: 0.22 P-value: 3.15E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Eosinophilic gastritis | ||||
| Example drug | Spiroglumide | Phase 2 | [2], [3], [4] | ||
| Tissue | Gastric antrum tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.34 Z-score: 1.4 P-value: 7.65E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Thyroid cancer | ||||
| Example drug | Demogastrin | Phase 1 | [2], [3], [5] | ||
| Tissue | Thyroid | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 1.00E-03 Z-score: 4.05E-03 P-value: 6.53E-01 |
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| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: -0.07 Z-score: -0.33 P-value: 1.38E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Progress medicinal chem PMC37H. Page(48). | ||||
| REF 5 | 99mTc-Demogastrin 2 for CCK 2-receptor scintigraphy in medullary thyroid carcinoma. J Nucl Med. 2008; 49 (Supplement 1):115P. | ||||
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